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Does giving a single dose of dexamethasone before wisdom tooth removal reduce pain and swelling afterward?

Effects of Pre-operative Dexamethasone (08 mg) on Post-operative Complications including Swelling and Pain after Removal of Impacted 3rd Molar Teeth

Status
Not yet recruiting
Phases
Phase 2
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12625001225404
Enrollment
60
Registered
2025-11-05
Start date
2025-12-12
Completion date
2026-02-12
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study is being carried out to see whether giving a small dose of the medicine dexamethasone before wisdom tooth surgery can help patients have less pain and swelling afterwards. The idea is that dexamethasone, which is a type of anti-inflammatory medicine, may make recovery easier and more comfortable. The study will compare patients who receive the medicine with those who do not, to find out if there is a clear benefit.

Interventions

Before removal of the impacted wisdom tooth, patients will receive a single 8 mg dose of dexamethasone along with the routine local anaesthesia. The drug will be injected locally at the surgical site just before the procedure begins. This is a one-time intervention, given only once, and the extraction itself usually takes about an hour, involving gum flap raising, bone cutting if needed, tooth removal, and suturing. The injection and the extraction will be performed by a postgraduate resident i

Before removal of the impacted wisdom tooth, patients will receive a single 8 mg dose of dexamethasone along with the routine local anaesthesia. The drug will be injected locally at the surgical site just before the procedure begins. This is a one-time intervention, given only once, and the extraction itself usually takes about an hour, involving gum flap raising, bone cutting if needed, tooth removal, and suturing. The injection and the extraction will be performed by a postgraduate resident in Oral and Maxillofacial Surgery under the supervision of faculty members at Khyber College of Dentistry. Because the dexamethasone is administered by the dentist directly in the clinic, adherence is ensured, and each administration will be documented in the patient’s medical records.

Sponsors

Dr Qazi Jawad Hayat - Khyber College of Dentistry
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

1) Teeth that requires Flap raising and Bone cutting. 2) No hypersensitivity to any drug including Dexamethasone, Penicillins, Metronidazole or Ibuprofen. 3) Patients from 18 years of age till 60 years of age.

Exclusion criteria

1)Patients having any systemic disease that effects wound healing. 2)Patients having Diabetes, or Any systematic condition that can be worsened by use of drugs mentioned. 3) Patients having pre-operative swelling. 4)Teeth in the vicinity of a tumour

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026