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The effect of clove oil as a topical analgesic during tooth restoration

A randomized controlled trial to evaluate the analgesic effect of clove oil applied topically during restorative tooth preparation in patients with occlusal caries

Status
Not yet recruiting
Phases
Phase 2
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12625001207404
Enrollment
132
Registered
2025-10-31
Start date
2025-11-01
Completion date
2026-01-01
Last updated
2025-11-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study will test whether clove oil can help reduce pain during tooth filling procedures. Adult patients with dental cavities will be randomly given either clove oil or a placebo oil before treatment. Their pain will be measured using a simple pain scale. The goal is to see if clove oil provides effective pain relief without the side effects of common pain medicines. This research hopes to make dental treatment more comfortable using a natural option.

Interventions

Name: Clove oil Description: Clove oil will be applied topically using a cotton pellet twice for 60 seconds, 10 minutes prior to restorative tooth preparation. Mode of delivery: Topical application on the tooth Duration: Single application prior to the procedure Dose: Two 60-second applications The researcher will administer clove oil by herself and will assess the adherence to intervention by direct observation

Sponsors

Ayesha Noor; Khyber College of Dentistry
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Primary purpose
Treatment

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
No

Inclusion criteria

• Adults aged 18–50 years • Presence of occlusal caries up to D2 level in posterior teeth • No clinical or radiographic evidence of periapical pathology

Exclusion criteria

• Pregnant or lactating women • Patients with systemic conditions affecting neural sensitivity or dental health (e.g., diabetes) • Use of desensitizing products or analgesics/NSAIDs within 24 hours • History of hypersensitivity to clove oil

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026