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Changes in selected markers of myocardial and skeletal muscle damage in the blood of long-distance runners

Changes in selected markers of myocardial and skeletal muscle damage in blood induced by long-distance running in outdoor conditions

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12625001193460
Enrollment
30
Registered
2025-10-30
Start date
2024-09-10
Completion date
2024-10-06
Last updated
2025-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The main aim of the research project will be to evaluate indicators of prooxidant-antioxidant balance, markers of skeletal muscle and heart damage, blood morphology. The expression of mRNA for selected genes in mononuclear cells (PBMC) from the blood of individuals before and after completing a marathon was also assessed. The study involved 30 men aged 35-50 with greater than or equal to 3 years of training experience who will participate in a continuous marathon and ultramarathon run during the Silesia Marathon event. The subjects will have their blood pressure and basic anthropometric parameters measured at rest and immediately after exercise. The subjects' eating habits and training characteristics between competitions will be assessed. Blood will be collected from the median cubital vein at three time points: at rest, immediately after exercise and 24 hours after exercise. Blood for the determination of the expression of selected genes will be collected at rest and 24 hours after exercise.

Interventions

The subject of the planned research is the assessment of selected biochemical markers in the blood of athletes participating in continuous running at marathon and ultramarathon distances during the Silesia Marathon event. At rest and immediately after exercise, the subjects will undergo blood pressure measurements and basic anthropometric measurements. During the race, their pace will be assessed. In addition, the subjects will be asked to complete a questionnaire on their eating habits and the

The subject of the planned research is the assessment of selected biochemical markers in the blood of athletes participating in continuous running at marathon and ultramarathon distances during the Silesia Marathon event. At rest and immediately after exercise, the subjects will undergo blood pressure measurements and basic anthropometric measurements. During the race, their pace will be assessed. In addition, the subjects will be asked to complete a questionnaire on their eating habits and the characteristics of the training they do between competitions (anticipated to take 30 minutes to complete). Blood will be collected from the median cubital vein at three time points: at rest, immediately after exercise, and 24 hours after exercise.

Sponsors

Ministry of Science and Higher Education
Lead SponsorGovernment body

Eligibility

Sex/Gender
Male
Age
35 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

1. healthy men (35-50 years), 2. voluntary agreement to the examination, 3. Training experience greater than or equal to 3 years, 4. athletes competing in the marathon and ultra distances 5. time for the marathon distance: 2 hours and 30 minutes to 3 hours and 30 minutes

Exclusion criteria

1. lack of consent to participate in the study, 2. failure to be available on the event day, 3. health contraindications to the procedure and collection of biological material.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026