None listed
Conditions
Brief summary
This study investigated whether adding tranexamic acid to the standard local anesthetic during septoplasty (nose surgery) reduces bleeding and improves the surgical field. We hypothesized that local tranexamic acid would significantly decrease blood loss, enhance surgical conditions, and increase surgeon satisfaction without raising risks.
Interventions
The intervention group will receive the intervention solution:
The intervention solution contained 5 ml 2% lidocaine and 0.5 ml epinephrine 1:100,000 plus 1 ml tranexamic acid (100 mg).
The intervention solution was given as a local injection into the septum mucosa using a syringe before the incision (as is usual in septoplasty).
The injection was performed by the same otolaryngologist who performed the surgery.
It was given once at the beginning of the procedure.
The method of administration i
The intervention group will receive the intervention solution: The intervention solution contained 5 ml 2% lidocaine and 0.5 ml epinephrine 1:100,000 plus 1 ml tranexamic acid (100 mg). The intervention solution was given as a local injection into the septum mucosa using a syringe before the incision (as is usual in septoplasty). The injection was performed by the same otolaryngologist who performed the surgery. It was given once at the beginning of the procedure. The method of administration is local injection via syringe. The injection protocol comprised a standardized volume of 10 ml for both groups. Distilled water was used as the diluent to achieve the target volume. In both groups, the surgeon administered the agent as a local injection within the surgical field.
Sponsors
Damascus University
Study design
Allocation
Randomised controlled trial
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Inclusion criteria comprised patients scheduled for elective septoplasty who met ASA physical status class I and were aged between 18 and 60 years.
Exclusion criteria
Exclusion criteria included: refusal to participate; patients with ASA class II or higher; impaired coagulation tests; history of thromboembolism or bleeding disorders; thrombocytopenia (low platelet count); documented use of anticoagulant medications; previous nasal surgery; concurrent rhinoplasty, sinus surgery, or turbinate surgery during septal repair; and known allergy to tranexamic acid.
Outcome results
None listed