None listed
Conditions
Brief summary
To measure mean of skin graft take with and without post graft negative pressure wound dressing, in patients needing skin graft coverage for wounds involving lower limbs. Hypothetically The mean of skin graft take is higher with the use of post-grafting negative pressure wound therapy (NPWT) in patients needing skin graft for wound coverage in lower limbs compared to conventional dressings. NPWT continuously drains excess fluid, preventing seroma and hematoma formation. It Ensures better graft adherence by reducing shear forces, reduces bacterial load and inflammation, promoting a conducive healing environment, promotes micro vascularization crucial in compromised wounds, Improves graft success, minimizing the need for additional grafts and reducing donor site complications. This study aims to compare skin graft take in patients treated with and without NPWT post-grafting, providing evidence for NPWT’s potential benefits.
Interventions
All cases will be done under general anesthesia or spinal anesthesia by plastic surgeon in hospital operation theatre. In intervention group wound bed will be prepared by wound wash and debridement, skin graft will be harvested from the thigh and spread on derma carrier (1:1.5) then meshed with skin graft mesher. Skin graft will be deployed on wound and secured in place with surgical staples. Non adhesive perforated layer (paraffin gauze) will be applied on skin graft, then fluffed sterile gauz
All cases will be done under general anesthesia or spinal anesthesia by plastic surgeon in hospital operation theatre. In intervention group wound bed will be prepared by wound wash and debridement, skin graft will be harvested from the thigh and spread on derma carrier (1:1.5) then meshed with skin graft mesher. Skin graft will be deployed on wound and secured in place with surgical staples. Non adhesive perforated layer (paraffin gauze) will be applied on skin graft, then fluffed sterile gauze will be applied over paraffin gauze and suction device will be attached which will maintain constant negative pressure of -125mmHg. Change of dressing will be done on 5th post-operative day. Details of the skin grafting procedure will be recorded, including graft type, size, and location.
Sponsors
Combined military hospital Rawalpindi
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Healthy volunteers
No
Inclusion criteria
Patients of all age groups with wounds suitable for skin grafting involving lower limb, including traumatic wounds, post burn defects, chronic ulcers, post infection soft tissue defects
Exclusion criteria
Patients with psychiatric illnesses that may interfere with study participation. Immunocompromised patients (e.g., HIV/AIDS, on immunosuppressive therapy). Patients with active malignancies. Patients with ischemic wounds not suitable for grafting. Patients with deranged coagulation profiles (e.g., INR > 1.5, platelet count < 50,000/µL).
Outcome results
None listed