Diagnostic yield of cryobiopsy vs other sampling modalities in Radial Endobronchial Ultrasound lung biopsy: cross-over randomised controlled trial

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Brief description of the study purpose This study is testing whether a newer biopsy technique, called cryobiopsy, can be used on its own to accurately diagnose lung nodules. It will also look at whether the order in which different biopsy methods are performed affects the accuracy of the diagnosis. Who is it for? You will be eligible if you are an adult who are scheduled to have a bronchoscopy with radial endobronchial ultrasound (R-EBUS) at Westmead Hospital or Westmead Private Hospital may be able to take part. Study details All participants who are eligible will undergo a bronchoscopy procedure using R-EBUS as part of their routine care. During this procedure, several different biopsy techniques will be performed: up to 6 forceps biopsies, 3 fine needle aspirations, 1 brushing, and up to 5 cryobiopsies. The order of sampling will be randomised. The tissue samples will be examined by pathologists to see which technique provides the most accurate diagnosis. It is hoped this research will show whether cryobiopsy can replace other methods, improving the accuracy and efficiency of diagnosing lung nodules and helping patients receive the right treatment sooner.

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