Personalised Risk Assessment and Infection Surveillance with Disease Modifying Therapies (PRISM) - A prospective registry and biorepository

Patients with auto-immune diseases receiving, or planning to receive, disease modifying therapies, will be included prospectively in the registry under an opt-out consent. Demographic, medical history, treatment history, vaccination history and infection events will be included. Participants may also be invited, with written informed consent, to participate actively by donating research samples including serology, blood cultures, and infection diagnostics at baseline, and at any pertinent event post enrolment, including infection on therapy, vaccination on therapy, augmentation to therapy or hospitalisation. Any pre-existing infection or treatment data from the medical-record will be reviewed and may be collected retrospectively.