None listed
Conditions
Brief summary
The focus of this study is to determine whether lung ultrasound (LUS) can predict poor lung outcomes in high-risk patients undergoing cardiac surgery and guide decisions for optimal oxygen delivery methods. This study will be a sub-study within the larger Nasal High-Flow Oxygen Therapy After Cardiac Surgery (NOTACS) Trial (registration record: NCT05308719), ethics registration record, SSA/2021/MNHHS/81052. Whilst cardiac surgery can provide several long-term benefits, the surgery is not without risks. Incidences of post-operative pulmonary complications (PPCs) (or lung complications) for patients undergoing open-heart surgery range from 5-90% depending on the definition of the complication. The identification of risk factors for developing PPCs and early diagnosis in the cardiac surgery population is of major importance. LUS has emerged as an excellent diagnostic tool in identifying a variety of pulmonary diseases and PPCs. We hypothesise that LUS will be an accurate predictor of PPCs and guide optimal respiratory support (oxygen therapy) in the high-risk cardiac surgery population.
Interventions
Recruited participants will have all undergone open-heart surgery and be recruited to the Nasal High-flow Oxygen Therapy After Cardiac Surgery (NOTACS) international multicentre trial (registration record: NCT05308719) whereby high-risk patients undergoing open-heart surgery are allocated to either conventional/standard oxygen therapy, or nasal high-flow oxygen therapy.
Two lung ultrasound scans will be completed postoperatively at two separate timepoints: 1. Pre-extubation (within four to 12 h
Recruited participants will have all undergone open-heart surgery and be recruited to the Nasal High-flow Oxygen Therapy After Cardiac Surgery (NOTACS) international multicentre trial (registration record: NCT05308719) whereby high-risk patients undergoing open-heart surgery are allocated to either conventional/standard oxygen therapy, or nasal high-flow oxygen therapy. Two lung ultrasound scans will be completed postoperatively at two separate timepoints: 1. Pre-extubation (within four to 12 hours pre-extubation) and 2. Post-extubation )within 12-16 hours post-extubation). The observation period for the primary outcome (postoperative pulmonary complications (PPCs)) will be seven days postoperatively.
Sponsors
The Prince Charles Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
As per NOTACS study criteria: • Adult patients undergoing cardiac surgery with cardiopulmonary bypass • One or more risk factors of post-operative pulmonary complications: 1. Chronic Obstructive Pulmonary Disease, 2. Asthma, 3. Lower respiratory tract infection in last four weeks, 4. Body mass index greater than or equal to 35kg/m2, 5. Current (within the last six weeks) heavy smokers (>10 pack years) No additional inclusion / exclusion criteria were set for this sub-study.
Exclusion criteria
• Deep-hypothermic circulatory arrest planned • Requirement for home ventilatory support (e.g. home continuous positive airway pressure for obstructive sleep apnoea)
Outcome results
None listed