None listed
Conditions
Brief summary
Temporomandibular disorders (TMD) are a group of conditions that affect the jaw joint (temporomandibular joint), the surrounding musculature, and the nerves related to chronic facial pain. Unlike other TMD therapy modalities photobiomodulation (PBM) is widely regarded for its clinical safety, non-invasiveness, anti-inflammatory and analgesic properties. PBM has been shown to be a beneficial adjuvant when used with other TMD therapies. While photobiomodulation has been reported in several studies to effectively relieve symptoms of TMD, the mechanism of action of photobiomodulation on the early inflammatory biomarkers remains unclear. Furthermore, little is known regarding the impact of how different wavelengths of near infared lasers impact the inflammatory biomarkers in the treatment of TMD. The purpose of this study is to shed light on the dynamics of photobiomodulation via the use of Infared lasers in influencing early inflammatory cytokines, such as TNF-A and IL-1B, in TMD therapy using only patient saliva samples. It is hypothesized that patients with TMD will have reduced levels of inflammatory markers following PBM treatment. This research will be conducted at the School of Dentistry and Oral Health, Griffith University, Gold Coast and at The Thirty Two- a private dental practice located at T28/129 Queen St, Gold Coast.
Interventions
Patients will be requested to expectorate saliva immediately before photobiomodulation therapy. Patients will chew on a paraffin wax block to stimulate saliva production for 2 minutes. Patients will then be asked to relax and administered photobiomodulation (PBM) treatment using near infared lasers on both sides of their TMJ. After 1 hour, patients will be asked to expectorate saliva once again. After 24 hours of treatment, patients will be requested to expectorate saliva for a final time. The e
Patients will be requested to expectorate saliva immediately before photobiomodulation therapy. Patients will chew on a paraffin wax block to stimulate saliva production for 2 minutes. Patients will then be asked to relax and administered photobiomodulation (PBM) treatment using near infared lasers on both sides of their TMJ. After 1 hour, patients will be asked to expectorate saliva once again. After 24 hours of treatment, patients will be requested to expectorate saliva for a final time. The experimental treatments involved in this study will take place at the Griffith University Dental Clinic, Gold Coast Campus and The Thirty Two, T28/129 Queen St, Southport. The wavelength of the laser is 1064 nm. the power of the laser is 80 W. the power of the laser is 50 J. the pulse frequency is 0.5 to 100 Hz. The duration is 10minutes. A dentist will be administering the treatment.
Sponsors
Griffith Univerisity Faculty of Medicine and Dentistry
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Patients that are diagnosed with TMD, are above the age of 18
Exclusion criteria
Patients with TMD that are using pharmaceutical drugs to treat TMD.
Outcome results
None listed