None listed
Conditions
Brief summary
The aim of this trial is to deliver high quality evidence of the effectiveness of Stroke Thrombectomy in patients with cancer. Who is it for? You would be eligible if you are 18 years or older, have acute ischemic stroke within 24 hours of onset, and moderate or severe stroke severity, a low pre-stroke disability, and large vessel occlusion on brain imaging and active cancer. Study details You would have clot extraction with a catheter inserted into blood vessel from the groin and navigate up to the brain. This research will help to understand if clot extraction for patients with active cancer and large vessel occlusion will help patients to resume cancer therapy
Interventions
Patients will have clot extraction or aspiration catheter in the angiographic suite. This procedure may be performed under general anaesthesia. This decision is up to the interventional radiologists performing the procedure. The procedure may take 1 hour but can be longer for complex anatomy or clot. Following the procedure the interventional neuroradiologists will document the procedure in electronic medical record. Post-intervention: A non-contrast Computed Tomography (CT) and CT Angiography w
Patients will have clot extraction or aspiration catheter in the angiographic suite. This procedure may be performed under general anaesthesia. This decision is up to the interventional radiologists performing the procedure. The procedure may take 1 hour but can be longer for complex anatomy or clot. Following the procedure the interventional neuroradiologists will document the procedure in electronic medical record. Post-intervention: A non-contrast Computed Tomography (CT) and CT Angiography will be performed 24-to-48-hour post intervention. At the investigator’s discretion, a repeat CT Perfusion or Magnetic Resonance Imaging (MRI) may be performed at 24-to-48 hr.
Sponsors
NHMRC
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients presenting with acute ischaemic stroke within 24 hours of stroke onset (in line with current criteria for thrombolysis). 2. National Institute of Health Stroke Scale (NIHSS)>4 3. Pre-stroke modified Rankin Score (mRS) score of 0-4 4. Patient’s age is 18 years and over (or as per local requirements) 5. Endovascular therapy (arterial puncture) within 90 minutes of initial CT brain. 6. Arterial occlusion on CT Angiography or MR Angiography (MRA) of large vessel occlusion (LVO) 7. Active cancer
Exclusion criteria
1. Patients presenting with acute ischaemic stroke >24 hours of stroke onset. 2. Intracranial haemorrhage identified by CT or MRI. 3. Rapidly improving symptoms at the discretion of the investigator 4. Pre-stroke modified Rankin Score (mRS) score of 1/2 MCA or ACA territory on non-contrast CT. 6. Contraindication to imaging with contrast agents (requirement for performing thrombectomy) 7. Any condition that, in the judgment of the investigator, could impose hazards to the patient if study therapy is initiated or affect the participation of the patient in the study. 8. Pregnancy
Outcome results
None listed