Coronary Artery Stenosis in Anti-Resorptive Users (CAESAR) Imaging Study

Physical measurements: weight and height will be taken at the site. Bone Imaging: Seven scan will be performed. Four will be using a high resolution peripheral quantitative computed tomography scanner (HR-pQCT) at the left leg and left arm. Participants will be undergoing this scan because they have enrolled in this study. These four scans will take approx. 30-40 minutes in total (as per protocol document). Three scans will be using dual energy x-ray absorbtiometry (DEXA) to assess bone mineral density (BMD) at the hip and spine. These three scans will take approximately 5-10 minutes in total (as per protocol document). These scans will be conducted only once, all within the same session. No contrast dyes will be used for these scans. Heart Imaging: One scan will be performed using a computed tomography coronary angiogram (CTCA) which will check the vessels that supply blood to the heart. This will take approx. 20-30 minutes (as per protocol document). Contrast dye will be used for this scan. Typically 50-100mL IV contrast is used, however the exact amount depends on the patients weight and other factors which will be considered by the medical team. This scan will be conducted either prior to or after the bone imaging, depending on radiologist/cardiologist availability. Most patients have had previous CTCA scans completed in the original CAESAR study. Typically, CAC screening is typically done on approximate 5- yearly basis thus, the timeline is optimal for helping participants’ health and wellbeing and guiding further management. CAC will be compared to this previous scan. One questionnaire will be completed over the phone, which will take approximately 30 minutes to complete. This will be done prior to the in-person imaging.