None listed
Conditions
Brief summary
This pilot study will investigate whether consuming purple and red-rich fruits can improve inflammation, oxidative stress, adiponectin levels, and memory in adults living with obesity. Over six weeks, participants will be randomly assigned to consume red dragon fruit juice (rich in betalains), Queen Garnet plum extract (rich in anthocyanins), or a placebo drink. Blood samples will be analysed for markers of inflammation (e.g. TNF-a, IL-6), oxidative stress, and adiponectin. Cognitive function, mood, and clinical health indicators will also be assessed. The results may help clarify the potential benefits of natural fruit compounds for metabolic and brain health.
Interventions
Brief name: Red fruit juice and Purple extract Intervention Arm 1 – Dragon Fruit Juice Group: Participants will consume 250 mL of red dragon fruit juice daily for 6 weeks. The juice contains approximately 55 mg of betalains per serving and will be provided in individual bottles. Participants are instructed to store the juice in their home refrigerator and consume one bottle per day. Dose: 250 mL/day Bioactives: ~55 mg betalains Duration: 6 weeks Mode of administration: Oral, self-administered at home Materials used: Bottled red dragon fruit juice Delivered by: Research team from the University of Wollongong Monitoring: Daily juice tracker; bottle return of unused juice at follow-up and paper diary. Arm 2 – Queen Garnet Plum Extract Group: Participants will consume 30 mL/day of Queen Garnet plum extract, providing approximately 300 mg of anthocyanins per day. The extract will be provided in individual daily doses and stored in the refrigerator. Dose: 30 mL/day Bioactives: ~300 mg anthocyanins Duration: 6 weeks Mode of administration: Oral, self-administered at home Materials used: Bottled extract Delivered by: Research team from the University of Wollongong Monitoring: Daily juice tracker; bottle return of unused juice at follow-up and paper diary. Adherence and Fidelity Monitoring: Participants will complete a daily intake tracker Used bottles and extract packaging will be collected at follow-up Verbal and written instructions provided at baseline clinic visit
Sponsors
Study design
Eligibility
Inclusion criteria
Participants will be eligible if they: - Are aged between 45 and 75 years; - Have a Body Mass Index (BMI) over 30 kg/m² (classified as obesity); - Are fluent in English (spoken and written); - Are able and willing to attend two clinical visits and consume the study beverage daily for 6 weeks; - Provide written informed consent.
Exclusion criteria
Participants will be excluded if they: - Have a current or past diagnosis of neurodegenerative disease (e.g. Alzheimer’s disease, Parkinson’s disease, multiple sclerosis); - Have major psychiatric disorders (e.g. schizophrenia, bipolar disorder); - Have been diagnosed with type 1 or type 2 diabetes mellitus; - Have clinically significant cardiovascular, renal, hepatic, or gastrointestinal disease; - Are currently undergoing treatment for cancer or have received chemotherapy or radiotherapy in the past 12 months; - Regularly consume dietary supplements or functional foods high in anthocyanins or betalains that cannot be discontinued during the study period; - Have allergies or intolerances to the intervention ingredients (e.g. pitaya, plum, raspberry); - Are pregnant, planning to become pregnant, or currently breastfeeding; - Are currently participating in another clinical trial or have participated in one within the last 30 days; - Are unable or unwilling to comply with the study protocol.