Impact of premenopausal risk-reducing bilateral salpingo-oophorectomy on non-cancer outcomes in BRCA1/2: 10-year follow up of a multicentre prospective controlled study.

A follow up at 10 years of the impact of premenopausal risk-reducing bilateral salpingo-oophorectomy on non-cancer outcomes in women who were at risk of developing ovarian cancer and who had undergone risk-reducing bilateral salpingo-oophorectomy (RRBSO). Outcomes include sexual function, menopause related quality of life and cognitive function.

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12625000907448

Acronym

WHAM-10

Enrollment

177

Registered

2025-08-20

Start date

2026-08-01

Completion date

2027-12-31

Last updated

2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This is a follow up study evaluating the impact of risk-reducing bilateral salpingo-oophorectomy (RRBSO) on sexual function, menopause symptoms and quality of life issues, bone health, cardiovascular health, sleep quality, depression/anxiety symptoms and cognitive function in high-risk, pre-menopausal women who participated in the WHAM study 10 years ago. Who is it for? You may be eligible if you participated in the WHAM study 10 years ago. Study details Participants will be assessed for non-cancer outcomes including sexual function, menopause symptoms and quality of life issues, bone health, cardiovascular health, sleep quality, depression/anxiety symptoms and cognitive function will be assessed at the 10 year follow up using the following: Blood tests, Bone mineral density scanning, Completion of questionnaires, cognitive function (online and face-to-face) testing Total time commitment no greater than 6hours. It is hoped that the result from this study will contribute to understanding the long-term effects of RRBSO to better inform future management.

Interventions

Women at risk of developing ovarian and/or breast cancer who have undergone RRBSO. Non-cancer outcomes including sexual function, menopause symptoms and quality of life issues, bone health, cardiovascular health, sleep quality, depression/anxiety symptoms and cognitive function will be assessed at the 10 year follow up using the following: Blood tests Bone mineral density scanning Completion of questionnaires cognitive function (online and face-to-face) testing Total time commitment no greate

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

This is a 10-year follow-up study of a prospective cohort study that compared high-risk premenopausal women who underwent risk reduction salpingo-oophorectomy (RRSO) (n=104) with age-matched, premenopausal women (n=102). Only women who were enrolled in WHAM will be invited to participate in WHAM-10.

Exclusion criteria

Not previously enrolled in the WHAM study.

Outcome results