None listed
Conditions
Brief summary
To determine whether acetic acid chromoendoscopy improves the detection rate of sessile serrated lesions during screening colonoscopy in average-risk patients. This outcome is measured by the proportion of colonoscopies that detect histologically confirmed sessile serrated lesion (SSL-DR).
Interventions
The intervention group underwent acetic acid chromoendoscopy using a 0.5% solution that was prepared fresh daily by diluting 3% or 5% acetic acid with normal saline. The concentration was determined based on preliminary dose-finding studies that balanced mucolysis effectiveness with minimal mucosal irritation. During withdrawal, approximately 30-50 mL of solution was applied to each colonic segment (cecum/ascending, transverse, descending/sigmoid) via a foot pump (Olympus). The timing is immedia
The intervention group underwent acetic acid chromoendoscopy using a 0.5% solution that was prepared fresh daily by diluting 3% or 5% acetic acid with normal saline. The concentration was determined based on preliminary dose-finding studies that balanced mucolysis effectiveness with minimal mucosal irritation. During withdrawal, approximately 30-50 mL of solution was applied to each colonic segment (cecum/ascending, transverse, descending/sigmoid) via a foot pump (Olympus). The timing is immediate (no delay). The procedure usually last 20minutes The Gastroenterologist using a foot pump administers the solution
Sponsors
Port Macquarie Gastroenterology
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Adults aged 18 years and older 2. Patients of Port Macquarie Gastroenterology 3. Scheduled for colonoscopy at Port Macquarie Private Hospital 4. Undergoing first-time or surveillance / screening colonoscopy 5. Average-risk individuals due for screening per national guidelines 6. Able to provide informed consent 7. Adequate bowel preparation anticipated 8. Complete colonoscopy to cecum expected
Exclusion criteria
1. Inflammatory bowel disease 2. Previous colorectal resection 3. Hereditary polyposis syndromes, Familial Adenomatous Polyposis (FAP) and Hereditary Nonpolyposis Colorectal Cancer (HNPCC). 4. Personal history of colorectal cancer 5. Pregnancy or lactation 6. Known allergy to acetic acid 7. ASA class IV-V
Outcome results
None listed