None listed
Conditions
Brief summary
This pilot study will assess the feasibility of a larger multicenter study to evaluate the association between a pregnant patient’s fibrinogen level on admission to hospital for labour and their risk of major bleeding (postpartum hemorrhage). Participants will be enrolled and consented in the antenatal clinic by trained research assistants. When the participant presents to hospital in labour, and routine intravenous access is inserted, a baseline fibrinogen level will be taken. This result will be blinded to both patient and treating clinician for three days after it is taken unless it produces a grossly abnormal result (fibrinogen <1.5g/L). All participants will be followed up to determine if they have a postpartum haemorrhage, the extent of haemorrhage, its clinical management and impact on the participant. If the pilot study is successful, the purpose of the multicenter study is to evaluate if fibrinogen levels can be used as a novel predictor of postpartum haemorrhage. Furthermore data from this pilot study can be used to inform our current practice regarding postpartum haemorrhage, and to improve our current management, if required.
Interventions
Prepartum serum fibrinogen levels taken on pregnant people aged greater than or equal to 18 years old admitted to hospital for the purpose of childbirth, requiring intravenous cannula insertion as part of their standard care on admission to birth suite or theatre.
The condition is pregnant people with low prepartum fibrinogen levels (defined as serum fibrinogen 500ml). Participants will be required to consent to collection of data as well as access to medical records by research staff for relev
Prepartum serum fibrinogen levels taken on pregnant people aged greater than or equal to 18 years old admitted to hospital for the purpose of childbirth, requiring intravenous cannula insertion as part of their standard care on admission to birth suite or theatre. The condition is pregnant people with low prepartum fibrinogen levels (defined as serum fibrinogen 500ml). Participants will be required to consent to collection of data as well as access to medical records by research staff for relevant data collection. Participant will also be required to complete two surverys, one at day 1 post-delivery (Obs-QoR-11) and one at day 30 post-delivery (Edinburgh postnatal depression scale) Participants will be observed from admission to discharge, with a text message follow-up survey at day 30 post-delivery
Sponsors
Eastern Health
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Pregnant people - Age: greater than or equal to 18 years old - Provided consent - Has a cannula inserted for delivery
Exclusion criteria
Age <18 years old Does not consent No IV cannulation required on admission Any patient who refuses blood products Patients with a known fibrinogen deficiency or disorder
Outcome results
None listed