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Enhancing Exercise Prescription and Adherence for Type 2 Diabetes Management for Adults with Long-COVID

Enhancing Exercise Prescription and Adherence for Type 2 Diabetes Management for Adults with Long-COVID: A Pilot Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12625000853448
Enrollment
10
Registered
2025-08-07
Start date
2025-08-19
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Our project aims to enhance the prescription and delivery of exercise to people with type 2 diabetes and long-COVID symptoms (e.g., breathlessness, fatigue) to allow return to, or uptake of, regular exercise. Mirroring the structure of the current Medicare-subsidised type 2 diabetes group exercise scheme, we will examine the feasibility and preliminary efficacy of a long-COVID symptom-guided exercise program after eight weeks.

Interventions

Potential participants will initially make contact via email or phone if they are willing to volunteer to take part in the study. Potential participants will initially be screened to ensure they meet all eligibility criteria. After providing written informed consent, the participants will undergo one in-person assessment at the Hunter Medical Research Institute (~3 hours). The intervention group will undergo an 8-week exercise program, delivered in groups of 2-6 by an Accredited Exercise Phys

Potential participants will initially make contact via email or phone if they are willing to volunteer to take part in the study. Potential participants will initially be screened to ensure they meet all eligibility criteria. After providing written informed consent, the participants will undergo one in-person assessment at the Hunter Medical Research Institute (~3 hours). The intervention group will undergo an 8-week exercise program, delivered in groups of 2-6 by an Accredited Exercise Physiologist. Participants will complete one 1-hour session per week, which will include 45 minutes of exercise and 15 minutes of education. Participants will be provided with an individualised home program to complete twice weekly, outside of the supervised sessions. The exercise sessions will include aerobic and resistance training, targeting all major muscle groups using body weight (e.g., wall push-ups), free weight (e.g., dumbbell bicep curl), and machine-based exercise (e.g., leg press). The exercise intensity will be prescribed based on long-COVID symptoms. The aim will be to achieve a Borg 0-10 category ratio dyspnoea or fatigue score of 4 to 6 (somewhat severe to severe). Exercise will be modified based on symptom responses to enable participants to exercise for high enough volumes and intensities to achieve physiological adaptations, without exacerbating unpleasant long-COVID symptoms. Exercises will be progressed on as as-needed basis. Adherence will be monitored through attendance checklists. In addition to the structured exercise component, the program will also include 15 minutes of education to help participants transition to self-management. These will be delivered by electronic slide presentations at the end of each session, and will cover such topics as safe intensity of movement, how to self-monitor symptoms and prevent activity-related symptom exacerbations, health behaviour change, exercise guidelines for T2D, goal setting, medications, and dietary guidelines. To enhance the likelihood of long-term behaviour change, the education sessions will target key constructs from Bandura’s Social Cognitive Theory (i.e., self-efficacy, goals, beliefs, and social support). The education has been specifically designed for this program. After the 8-week program, participants will attend the Hunter Medical Research Institute for their follow-up assessment (~3 hours).

Sponsors

University of Newcastle
Lead SponsorUniversity

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Blinded (masking used) (Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Adults over the age of 18 years diagnosed with type 2 diabetes who are experiencing long-COVID symptoms that reduce exercise tolerance (determined as a modified Medical Research Council dyspnoea score of or over 1 and/or fatigue that was not present pre-COVID; >12 weeks following confirmed SARS-CoV-19 infection).

Exclusion criteria

People will be ineligible if they have any condition as per the absolute contraindications to exercise outlined by the American College of Sports Medicine including, but not limited to: unstable angina; recent (within the past four weeks) myocardial infarction; coronary artery disease; uncompensated heart failure; New York Heart Association functional classification II-IV; severe valvular illness; pulmonary disease; uncontrolled hypertension (systolic blood pressure > 200 mmHg and/or diastolic blood pressure > 110 mmHg); renal failure (chronic kidney disease stages IV-V); cardiomyopathy. People will also be ineligible for: having type 1 diabetes, not being able to complete pre-COVID-19 activities of daily living and occupation within tolerable symptom limits, meeting the physical activity guidelines (150minutes/week moderate intensity or 75minutes/week vigorous intensity exercise), planned medical operations during the research period, a physical condition whereby exercise training would be inappropriate, pregnant or expecting to be pregnant during the study period, and non-English speaking.

Outcome results

None listed

Source: ANZCTR · Data processed: Aug 10, 2026