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Strengthening Memory and Anxiety Reduction Trial (SMART)

Making it stick: The effect of memory rehearsal on exposure therapy outcomes for childhood anxiety disorders.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12625000772448
Acronym
SMART
Enrollment
0
Registered
2025-07-22
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Outcomes for child anxiety treatment are suboptimal. Exposure therapy is the key technique to reduce anxiety, and involves facing the feared situation to learn that it is safe (i.e., safety learning). However safety learning can be forgotten, and fears come back. This clinical trial will assess whether adjunctive memory rehearsal after exposure therapy enhances outcomes and prevents relapse. Results will advance understanding of treatment mechanisms and optimise child anxiety treatment.

Interventions

Children will complete six weekly one-hour exposure therapy sessions targeting anxiety, along with between-session memory rehearsal training activities. Exposure therapy tasks will be tailored to each participants' specific anxiety disorder. For example, children with a primary fear of public speaking may engage in exposure tasks such as delivering a speech in front of their parents, presenting to one unfamiliar adult, or speaking in front of a small group of unfamiliar adults. In contrast, a

Children will complete six weekly one-hour exposure therapy sessions targeting anxiety, along with between-session memory rehearsal training activities. Exposure therapy tasks will be tailored to each participants' specific anxiety disorder. For example, children with a primary fear of public speaking may engage in exposure tasks such as delivering a speech in front of their parents, presenting to one unfamiliar adult, or speaking in front of a small group of unfamiliar adults. In contrast, a child with a phobia of the dark might participate in activities such as playing with glowsticks in a dark room, playing hide-and-seek in a dimly lit environment, or taking a nighttime walk with a torch. Children will be guided through exposure tasks in a gradual, step-by-step manner at their own pace. Sessions will be delivered by Provisional, Registered and Clinical Psychologists with specialist training in conducting exposure therapy with children. The memory rehearsal training is designed to help children recall specific memories of completing their exposure tasks and strengthen recall for the safety learning they have gained during the session. Children will complete a brief (~10minute) online questionnaire three times per week between exposure sessions, which will involve answering a set of standardised questions focsued on recalling the exposure tasks they completed during the session, their original threat expectancies, whether the negative events happened, and what they learned by doing the exposure task(s). Parents will be sent a link to the child's memory rehearsal questionnaire via SMS and will asssit children to answer the standardised questions. Adherence will be monitored via online survey completion.

Sponsors

Macquarie University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
8 Years to 12 Years
Healthy volunteers
No

Inclusion criteria

(1) Primary DSM-5 anxiety disorder or Obsessive Compulsive Disorder (OCD), based on a structured diagnostic interview (greater than or equal to 4 on the Anxiety Disorders Interview Schedule for Children [ADIS-C/P; Silverman & Albano, 1996]). (2) Aged 8-12 years (3) Children and their parents must be proficient in reading and writing in English. (4) Comorbidity with other internalizing and externalizing disorders is permissible, provided these are secondary diagnoses and/or not excluded diagnoses. (5) Willingness to provide informed consent and willingness to participate and comply with the study requirements.

Exclusion criteria

(1) Current clinically significant suicidality or suicidal behaviours (2) Concurrent psychological treatment (3) Pharmacotherapy: Current use of antidepressant or benzodiazepine medication. Other psychotropic medications are permitted provided the child has been on a stable dose for at least 8 weeks prior to study enrolment. (4) Diagnosis of selective mutism, conduct, bipolar or substance use disorder, psychosis, autism spectrum disorder, intellectual impairment or pervasive developmental disorder. (5) Considered at risk due to physical abuse, sexual abuse or extended school refusal.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026