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Study of pre-hospital whole blood transfusion in frontline trauma in Aotearoa New Zealand, comparing platelet-rich whole blood versus platelet-poor whole blood in major traumatic haemorrhage

Study of Whole Blood in Frontline Trauma in Aotearoa: A randomized controlled feasibility study assessing Prehospital Platelet-Rich Whole Blood versus Platelet-Poor Whole Blood in Major Traumatic Haemorrhage

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12625000719437
Acronym
SWiFT Aotearoa
Enrollment
11
Registered
2025-07-07
Start date
2025-12-02
Completion date
2029-07-27
Last updated
2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This is a randomized controlled blinded feasibility study assessing prehospital platelet-rich whole blood versus platelet-poor whole blood in major traumatic haemorrhage. The trial will enroll all eligible patients cared for by the Helicopter Emergency Medical Service providing care to the patients.

Interventions

Platelet-rich whole blood is defined as having >50% of post-filtration platelet content at expiry. The actual platelet content varies depending on the blood donor. Transfusion of platelet-rich whole blood in pre-hospital traumatic haemorrhage will follow Northern Rescue Helicopter's standard clinical practice as outlined in Appendix 3 & 4. The protocol outlines the use of the ABC score to identify patients in haemorrhagic shock. The rate is as fast as possible, given that the patient is in sho

Platelet-rich whole blood is defined as having >50% of post-filtration platelet content at expiry. The actual platelet content varies depending on the blood donor. Transfusion of platelet-rich whole blood in pre-hospital traumatic haemorrhage will follow Northern Rescue Helicopter's standard clinical practice as outlined in Appendix 3 & 4. The protocol outlines the use of the ABC score to identify patients in haemorrhagic shock. The rate is as fast as possible, given that the patient is in shock. The HEMS team has an extensive record keeping system that will be used for data in the trial. No additional blood components are available pre-hospital for transfusion. Northern Rescue Helicopter already have a clinical record keeping system for pre-hospital care and this will be reviewed as part of the trial. One or both units will be transfused prehospital with any remaining blood from the two units transfused on arrival at the hospital. Administration of the blood in the prehospital environment will be by team comprising of a Prehospital and retrieval medicine doctor and a critical care paramedic.

Sponsors

New Zealand Blood Service
Lead SponsorGovernment body

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender
All
Healthy volunteers
No

Inclusion criteria

1. Patient who has suffered trauma 2. Attended by a participating Northern Rescue clinical team 3. Requires prehospital blood transfusion to treat traumatic haemorrhagic shock

Exclusion criteria

1. No intravenous or intraosseous access (should be assessed prior to opening box) 2. Knowledge that patient will object to being given blood transfusion for any reasons 3. Blood already administered on-scene, prior to arrival of Northern Rescue 4. Patients experiencing non-traumatic haemorrhage

Outcome results

None listed

Source: ANZCTR · Data processed: Jul 23, 2026