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Evaluation of an Innovative Pathway Through Cardiac Rehabilitation for Individuals with Postural Orthostatic Tachycardia Syndrome (POTS)

Feasibility, Effectiveness and Acceptability of a Tailored Rehabilitation Pathway through Cardiac Rehabilitation for Individuals with Postural Orthostatic Tachycardia Syndrome (POTS)

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12625000699460
Enrollment
60
Registered
2025-07-01
Start date
2025-08-25
Completion date
2026-03-30
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

In recent years, there has been a notable increase in the prevalence of Postural Orthostatic Tachycardia Syndrome (POTS), a common form of dysautonomia. POTS is a debilitating condition resulting in exercise intolerance, a diminished ability to complete activities of daily living and profoundly impacts quality of life. Access to health care and services, including rehabilitation tailored for individuals with POTS is limited across Australia. Tailoring traditional cardiac rehabilitation services to better accommodate for individuals with POTS could be key to bridging the gaps in access to care for this cohort. This project aims to evaluate the feasibility, effectiveness and acceptability of the integration of a tailored rehabilitation pathway, reviewed by people with lived experience with POTS, into an existing cardiac rehabilitation service. This pathway will provide patients with 12 weeks of supervised exercise rehabilitation (phase one) before transitioning patients to a further 12 weeks of unsupervised exercise (phase two). At three timepoints, assessments will be completed to evaluate the impact of rehabilitation on exercise tolerance, symptom severity and quality of life. Patients will be followed up via phone across phase two to evaluate the maintenance of exercise after the completion of the supervised rehabilitation program. This research has potential to redirect the future of POTS rehabilitation in the public health system, bridging the existing gaps to care whilst importantly supporting improvements in exercise tolerance, health-related quality of life and activities of daily living for people with POTS.

Interventions

Tailored POTS Rehabilitation Pathway This study is a single-arm uncontrolled clinical trial including both quantitative and qualitative components. Rehabilitation will be completed in two phases. Phase one involves 12 weeks of supervised rehabilitation sessions. Two one-hour supervised sessions, separated by at least one day, will be completed either in person or virtually each week. In person rehabilitation sessions and assessments will be completed in the Jaghu Gym (Hayden Centre) or delivere

Tailored POTS Rehabilitation Pathway This study is a single-arm uncontrolled clinical trial including both quantitative and qualitative components. Rehabilitation will be completed in two phases. Phase one involves 12 weeks of supervised rehabilitation sessions. Two one-hour supervised sessions, separated by at least one day, will be completed either in person or virtually each week. In person rehabilitation sessions and assessments will be completed in the Jaghu Gym (Hayden Centre) or delivered out of the rural hospitals (Laidley, Esk, Gatton and Boonah) within the West Moreton HHS. Virtual rehabilitation sessions will be delivered in real-time via the Queensland Health Virtual Clinic. Supervised exercise sessions will completed in a small group (maximum 4 participants). Three in-person assessments will be completed across phase one (pre, mid and post). Rehabilitation exercises will be individualised based on subjective information gathered during the initial assessment completed pre-rehabilitation. Rehabilitation sessions will include a combination of aerobic and resistance exercises. Initial aerobic exercise modalities may include recumbent cycling, rowing and swimming. As tolerated, upright cycling, walking or the elliptical may be introduced, Strength or resistance exercises will focus on lower body and core strength. Exercises may be body weight or utilise a resistance band, Example strength exercise include: leg extension, leg curl, leg press, calf raises, chest press and row. Exercise prescription will be gradually progressed weekly throughout the program based on assessment results and participant feedback. Phase two involves a further 12 weeks of unsupervised exercise. Participants will be provided with a home exercise program to complete during these unsupervised exercise sessions. During each week of phase two, participants will be asked to undertake four sessions, with each session lasting up to one-hour. Session duration will be individualised based on the duration achieved during the final supervised exercise sessions. Two phone reviews will be completed across this 12 week period. Intervention adherence will be assessed through supervised session attendance and unsupervised session completion discussed at assessments and during phase two phone reviews. Rehabilitation sessions, assessments and follow up phone reviews will be completed by the principal investigator (Accredited Exercise Physiologist with >3 years of clinical experience in Cardiopulmonary rehabilitation).

Sponsors

Ipswich Chronic Conditions Service - West Moreton Health
Lead SponsorHospital

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
16 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Patients will be eligible to be included in the study if they have previously received a diagnosis of Postural Orthostatic Tachycardia Syndrome by a cardiologist and/or if the patient meets diagnostic criteria for POTS during an active stand test. Patients who are 16 years of age or older will be eligible, as late adolescence is a common time for the onset of POTS symptoms and consequential diagnosis. Patients must also provide written consent to engage with the rehabilitation program to be included in the project. Parental or guardian consent will also be requested for any patient under the age of 18 years. Diagnostic criteria for POTS is defined in the literature as: - A heart rate increase of 30 beats per minute (BPM) or more (40 BPM or more in children and adolescents) and/or a heart rate that exceeds 120 BPM within the first 10 minutes of quiet standing - Absence of orthostatic hypotension/ absence of a blood pressure drop of more than 20/10 mmHg on standing - Symptom duration of at least 3 months

Exclusion criteria

Patients will be excluded from the study should they be unable to provide informed consent to engage with the program or are unable to comply with the rehabilitation program requirements (eg. unable to attend available sessions). Patients will also be excluded from the study if they have a comorbidity or musculoskeletal complaint that would prevent safe engagement in exercise training as per the American College of Sports Medicine and local service contraindications

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026