None listed
Conditions
Brief summary
To my knowledge, locally limited research comparing the effects of ibuprofen and naproxen on pulp sensibility tests is available. The frequent use of analgesics, the significance of pulpal sensibility tests in accurate diagnosis, and the potential impact of analgesics on pulpal sensibility tests highlight the need for additional research into how commonly used analgesics affect the outcomes of pulpal sensibility tests. This study increases knowledge of a local body of evidence, and a better treatment plan could be proposed based on the results.
Interventions
Arm 1: Ibuprofen Group
Drug name (INN): Ibuprofen
Dose administered: 400 mg
Mode of administration: Oral tablet
Duration of administration: Single dose
Timing of follow-up measurements: Electric Pulp Test (EPT) will be performed at baseline (0 minutes), and subsequently at 20, 40, and 60 minutes after administration.
Who delivers intervention: A qualified dental surgeon with clinical training in endodontics will supervise the drug administration and perform all follow-up testing.
Setting:
Arm 1: Ibuprofen Group Drug name (INN): Ibuprofen Dose administered: 400 mg Mode of administration: Oral tablet Duration of administration: Single dose Timing of follow-up measurements: Electric Pulp Test (EPT) will be performed at baseline (0 minutes), and subsequently at 20, 40, and 60 minutes after administration. Who delivers intervention: A qualified dental surgeon with clinical training in endodontics will supervise the drug administration and perform all follow-up testing. Setting: Department of Operative Dentistry and Endodontics, Khyber College of Dentistry Fidelity monitoring strategy: The oral dose will be administered directly under supervision of the dental surgeon to ensure compliance with the intended protocol. Arm 2: Naproxen Group Drug name (INN): Naproxen Dose administered: 500 mg Mode of administration: Oral tablet Duration of administration: Single dose Timing of follow-up measurements: Electric Pulp Test (EPT) will be performed at baseline (0 minutes), and subsequently at 20, 40, and 60 minutes after administration. Who delivers intervention: A qualified dental surgeon with clinical training in endodontics will supervise the drug administration and perform all follow-up testing. Setting: Department of Operative Dentistry and Endodontics, Khyber College of Dentistry Fidelity monitoring strategy: The oral dose will be administered directly under supervision of the dental surgeon to ensure compliance with the intended protocol.
Sponsors
Khyber College of Dentistry
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Adults between 18 and 65 years with pain due to SIP. Patients respond with lingering pain after removal of EPT from the tooth surface. Patients who had not used any analgesic or central nervous system depressant in the past 6 hours prior to their visit
Exclusion criteria
Patients for whom ibuprofen and naproxen are contraindicated. Young permanent teeth with incomplete root apex. Systemically ill patients. Patients whose teeth do not respond to EPT. Presence of periapical disease.
Outcome results
None listed