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Dual therapy with minocycline and itraconazole in the treatment of superficial fungal infections

Dual therapy with minocycline and itraconazole in the treatment of resistant dermatophytosis : double blind therapeutic comparative case - control study in participants with recurrent dermatophytosis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12625000611426
Enrollment
240
Registered
2025-06-12
Start date
2024-02-05
Completion date
2025-02-01
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Evaluation of New treatment modality for resistant fungal infection of skin by using minocycline and itraconazole in a case group and itraconazole only in a control group . The study hypothesis is that the concurrent administration of minocycline and itraconazole led to rapid and complete recovery with a low recurrence rate and minimal side effects

Interventions

The case group : receive minocycline tablet 80 mg orally once daily in addition to itraconazole capsule 100 mg orally once daily for 4 to 6 weeks The strategy that used to monitor adherence to the intervention is drug tablet return The group allocation is determined by physician discretion ? in form that the first 10 participants receive control , next 10 receive intervention , etc

Sponsors

Duha khaleel Ismail / Al sader teaching hospital - Basrah
Lead SponsorIndividual

Study design

Allocation
Non-randomised trial
Primary purpose
Treatment
Masking
Blinded (masking used) (Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

All pateints with recurrent dermatophytosis

Exclusion criteria

Patients with chronic liver and renal diseases, congested heart failure or any chronic heart diseases, pregnant and lactating women, patients with known allergies to both used drugs, poor compliance patients and children below 18, and patients older than 65 years old,

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026