None listed
Conditions
Brief summary
The primary purpose of this study is to see if titration of statin therapy can improve adherence and therefore outcomes while reducing the known side effects of statin therapy
Interventions
The intervention involves gradually adjusting the dose of statin medication for patients who have experienced a non-ST elevation myocardial infarction (NSTEMI). Starting with a lower dose, the medication will be titrated upward over time until the desired effect is achieved. This approach aims to minimize potential side effects associated with statin therapy while still providing the cardiovascular benefits.
The dose will be commenced at Atorvastatin 10mg daily and doubled every month for 4 mon
The intervention involves gradually adjusting the dose of statin medication for patients who have experienced a non-ST elevation myocardial infarction (NSTEMI). Starting with a lower dose, the medication will be titrated upward over time until the desired effect is achieved. This approach aims to minimize potential side effects associated with statin therapy while still providing the cardiovascular benefits. The dose will be commenced at Atorvastatin 10mg daily and doubled every month for 4 months until a maximum dose of 80mg daily is obtained. 10mg daily for one month, 20mg daily for one month, 40mg daily for one month and 80m daily for one month. The titrated dose will be continued for one month until a maximum dose is achieved and will be continued daily regularly The administation will be an oral tablet Drug adherence will be monitored by self reporting check list that will be provided to the patient that they can record when they have taken the medication and if they have any side effects and then a 6 monthly standard blood test will be done post their non ST elevation MI to assess lipid reduction (as per standard management protocol for NSTEMI)
Sponsors
Sunshine Hospital, Western Health
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Key Inclusion Criteria: 1. Diagnosis of Non-ST Elevation Myocardial Infarction (NSTEMI) 2. Prescribed statin therapy as part of post-NSTEMI management 3. Ability to provide informed consent 4. Age 18 years or older
Exclusion criteria
Key Exclusion Criteria: 1. History of statin intolerance or allergy 2. Inability to adhere to the study protocol or complete required assessments 3. Contraindication to statin therapy 4. Severe comorbidities or conditions affecting life expectancy 5. Participation in another clinical trial involving lipid-lowering medications
Outcome results
None listed