None listed
Conditions
Brief summary
A clear relationship between diet and the gut microbiome exists, and supplementation and/or modifications to habitual diet may help modulate the gut microbiota. Probiotics and honey exert positive effects on the gut microbiome and supplementation of honey and probiotics in combination may improve mood and cognitive function, as well as sleep. The objective of this explorative study is to evaluate the effects of a combination of honey and probiotics on mood, anxiety, and sleep outcomes in physically active adults.
Interventions
This study will be a randomised, placebo-controlled, double-blind, crossover trial. There will be two treatment arms: Honey + probiotics (HP) or placebo (glucose syrup). Participants will be required to consume the supplement daily; either once in the morning or once in the evening, for a period of 2 weeks. The HP product contains 4g of manuka honey (UMF 15), 0.96g rewarewa honey, and 35 mg bacillus coagulans probiotics per dose (1 million CFU). There will then be a two-week washout period befor
This study will be a randomised, placebo-controlled, double-blind, crossover trial. There will be two treatment arms: Honey + probiotics (HP) or placebo (glucose syrup). Participants will be required to consume the supplement daily; either once in the morning or once in the evening, for a period of 2 weeks. The HP product contains 4g of manuka honey (UMF 15), 0.96g rewarewa honey, and 35 mg bacillus coagulans probiotics per dose (1 million CFU). There will then be a two-week washout period before supplementing with the alternative (HP or PL) for two-weeks. The HP and PL will be encapsulated in opaque gelatin capsules and will be visually identical to each other. Weekly text messages will be sent to participants to monitor adherence to the supplementation protocols.
Sponsors
University of Auckland
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Aged 18 years and over Exercise > 2.5 hours per week, ' Not currently supplementing with probiotics.
Exclusion criteria
Psychiatric or neurological disorders, Coeliac disease, lactose intolerance, allergies or other ongoing illnesses (i.e., irritable bowel syndrome, diabetes, ulcerative colitis), Recent antibiotic treatment (i.e., < 3 months before the beginning of the study).
Outcome results
None listed