Comparison of efficacy of exosomes vs platelet rich plasma therapy in treatment of androgenetic alopecia

This study aims to compare the efficacy of exosomes versus PRP in the treatment of Androgenetic alopecia by using photographic assessment, hair pull test and patient self-assessment questionnaire over a period of 6 months. The enrolled patients will be randomly divided into two groups using the lottery method, Group A and B, each with 40 participants. GROUP A: Group A will receive treatment with exosomes intradermally at 0,1 and 3 months. Exosomes used are GFC CELL, consist of Leucoexo 97% having GFC CELL EXO SCALP 9700 powder and EXO SCALP Pep9 solution. The scalp will be cleaned with spirit and nerve block will be given by using the local injection, lignocaine, by insulin syringe at supratrochlear, supraorbital, and occipital region. Exosomes will then be injected at a strength of 2 to 10 billion particles/5ml, at a dose of 0.1 ml/cm2 of scalp. Patients will be observed for 1-hour post procedure for any adverse effects and will be instructed not to wash or massage their hair and avoid heavy activities for 48 hours after the injection. Exosomes will be administered by Dermatologist in the dermatology clinic, Combined Military Hospital, Quetta. Participants will be assessed at 0,1, 3, and 6 months. Serial photographs will be taken at each assessment. The efficacy of both groups will be evaluated using the hair pull test, global photography, patient and physician satisfaction questionnaire.