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Developing a Novel Algorithm to Exclude Deep Vein Thrombosis in the Emergency Department

Developing a Novel Algorithm to Exclude Deep Vein Thrombosis in the Emergency Department

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12625000541404
Acronym
DNA-DVT
Enrollment
1000
Registered
2025-05-28
Start date
2025-06-02
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Vascular ultrasounds are a limited resource and not always available in Emergency Departments. Similarly, current clinical decision rules are either too subjective or burdensome to result in high compliance in the Emergency Department. This study aims to derive a simple clinical decision rule to safely exclude the diagnosis of DVT and reduce the amount of vascular ultrasounds performed in the ED.

Interventions

A retrospective cohort study (up to 4 years of Emergency Department (ED) presentations) reviewing historical risk factors, examination findings and d dimer levels and the ability to combine these into a simple score to accurately exclude the diagnosis of deep vein thrombosis (DVT) Data will be reviewed from electronic medical records for patients presenting to the Emergency Departments at Royal North Shore Hospital and Hornsby Kuringgai Hospital between 1 January 2021 and 31 December 2024. Reco

A retrospective cohort study (up to 4 years of Emergency Department (ED) presentations) reviewing historical risk factors, examination findings and d dimer levels and the ability to combine these into a simple score to accurately exclude the diagnosis of deep vein thrombosis (DVT) Data will be reviewed from electronic medical records for patients presenting to the Emergency Departments at Royal North Shore Hospital and Hornsby Kuringgai Hospital between 1 January 2021 and 31 December 2024. Records will be assessed during a single presentation and it will be noted if the patient has re-presented within the following 14 days. A review of medical records for history and examination findings as well as investigation results of D dimer blood results and Vascular US imaging reports will be collected. The novel algorithm will be developed using statistical analysis (both regression analysis and bootstrapping) to determine a combination of risk factors that are sufficiently sensitive to exclude DVT.

Sponsors

Northern Sydney Local Health District
Lead SponsorGovernment body

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Adult patients Presented to Royal North Shore Hospital or Hornsby Kuringgai Hospital Emergency Department with a suspected DVT Underwent both D dimer and Vascular ultrasound within 36 hours

Exclusion criteria

Patients who have not undergone both D dimer and lower limb ultrasound testing Patients presenting with another primary concern, for example chest pain or dyspnoea

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026