None listed
Conditions
Brief summary
Systane Hydration is a lubricating eye drop with unique features and ingredients that may support corneal healing and reduce ocular surface inflammation. This project aims to investigate whether eye drops containing hyaluronic acid and hydroxypropyl guar improve the rate of corneal healing following transepithelial photorefractive keratectomy (tPRK) laser eye surgery, compared to standard carboxymethylcellulose drops. Secondary aims include evaluating the impact of the eye drops on vision and patient-reported comfort levels using a modified dry eye symptom scale. tPRK is an ideal model for assessing corneal healing, as a standard-sized epithelial defect is created in each eye during laser ablation. This controlled setting enables consistent comparison of healing outcomes between treatment groups.
Interventions
Comparison of carboxymethylcellulose (comparator) & hyaluronic acid and hydroxypropyl guar (intervention) lubricating eyedrops as part of standard post-laser refractive eye surgery care.
All participants will be given two separate eyedrops unlabelled eye drops and are randomised and masked to which eye is receiving the intervention e.g. hyaluronic acid and hydroxypropyl guar (intervention) lubricating eyedrops and which eye is receiving the standard comparator (carboxymethylcellulose). Each bot
Comparison of carboxymethylcellulose (comparator) & hyaluronic acid and hydroxypropyl guar (intervention) lubricating eyedrops as part of standard post-laser refractive eye surgery care. All participants will be given two separate eyedrops unlabelled eye drops and are randomised and masked to which eye is receiving the intervention e.g. hyaluronic acid and hydroxypropyl guar (intervention) lubricating eyedrops and which eye is receiving the standard comparator (carboxymethylcellulose). Each bottle is labelled R and L for right and left eyes respectively and participants are told to administer one drop per eye, four times a day throughout the 30 day post-operative period. The eye drop treatment regime will commence on the same day as the laser eye surgery and used 4 times a day per eye at evenly spaced intervals. To ensure adherence to the protocol, the researcher who is also masked to the treatment will ensure that eye drops are being used correctly at the Day 1 and Day 3 post op review.
Sponsors
Ben LaHood - Adelaide Eye & Laser (Level 1, 215 Greenhill Road Eastwood South Australia 5063)
Study design
Allocation
Randomised controlled trial
Intervention model
Other
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
Age: 18-50 Eligible for transepithelial photorefractive keratectomy
Exclusion criteria
No, this study compares the recovery after laser eye surgery, participants must have a refractive error to participate. Participants who are emmetropic (perfect vision) will be excluded from this study. Participants who do not meet criteria for transepithelial photorefractive keratectomy or have a prior history of ocular surgery, trauma or any existing eye conditions will also be excluded from this study.
Outcome results
None listed