None listed
Conditions
Brief summary
This study will aim to establish whether dietary fibre added to normal tube feeding food can increase bacterial diversity in the GI tract in people who are critically ill and are receiving treatment with a breathing machine in the ICU. Information on GI bacteria will be collected from stool samples or cotton swabs that have wiped the bottom. It will also aim to collect information on whether the use of use of dietary fibre can lead to patients improving more quickly, such as by enabling liberation from the breathing machine earlier or having fewer infections caught in hospital. This study aims to investigate if "good bacteria" in the intestines can be increased during critical illness adding fibre to food.
Interventions
The dose administered: 10 grams of Inulin dissolved in 50mL of water.
The mode of administration: as a bolus through an existing nasogastric tube (or orally once extubated)
The frequency and duration of this intervention: once daily for 7 days (only while in ICU)
This intervention will commence as soon as possible after patient is mechanically ventilated, consent obtained from medical treatment decision maker (MDTM) and allowed enteral nutrition.
Adherence to administration of intervention will
The dose administered: 10 grams of Inulin dissolved in 50mL of water. The mode of administration: as a bolus through an existing nasogastric tube (or orally once extubated) The frequency and duration of this intervention: once daily for 7 days (only while in ICU) This intervention will commence as soon as possible after patient is mechanically ventilated, consent obtained from medical treatment decision maker (MDTM) and allowed enteral nutrition. Adherence to administration of intervention will be by monitoring EMR.
Sponsors
Royal Melbourne Hospital
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
a. Adults greater than or equal to 18 years of age b. Admitted to ICU c. Expected to remain Mechanically ventilated for 48 hrs d. Allowed enteral nutrition at the time of randomization
Exclusion criteria
a. Death during ICU admission deemed to be inevitable b. Patients unable to be fed enterally c. Pregnancy d. Surgery involving the GI lumen in the preceding 30 days e. Currently has a colostomy or ileostomy f. Pregnancy or lactation g. Has received enteral nutrition for more than 72 hrs prior to randomisation
Outcome results
None listed