None listed
Conditions
Brief summary
This study aims to investigate the impact of plan parameters and optimisation approaches on plan monitor units (MUs) and corresponding physics quality assurance (QA) results. Who is it for? Patients who have been diagnosed with intact brain metastases and/or post-operative cavities after resection of brain metastatic disease, and planned with HyperArc and treated on the stereotactic linear accelerator at Canberra Region Cancer Centre from September 2022 to March 2025 will be retrospectively analysed for this study. Study details Once participants are deemed eligible, their existing radiation treatment plans will be randomly selected to provide a wide range of plan characteristics such as number of lesions, size of lesions, shape of lesions, distance from isocentre, proximity to healthy organs and use of optimisation structures. These plans will be de-identified and replanned, changing one variable at a time to observe the results on plan complexity (MUs) and physics QA results. These plans will be ensured clinical acceptability by the principal investigator. After replanning, the impact of plan characteristics on plan complexity and physics QA results will be observed and from that data, MU limits will be developed which are tailored on specific plan characteristics. It is hoped that the results from this study will provide a better understanding of the change in complexity of HyperArc SRS plans depending on particular plan characteristics and see the implementation of MU limits result in a more seamless SRS planning workflow which balances clinical acceptability with deliverability and safety.
Interventions
As this is a retrospective study using existing medical records of patients who have completed their course of radiation treatment from Sept 2022 to March 2025, there is no direct involvement from participants and no treatment is given to patients. The study will only use be using the existing radiation treatment plans and replanning them with different approaches/ parameters, then observing the correlation between plan complexity (monitor units) and physics plan quality assurance (QA) results.
As this is a retrospective study using existing medical records of patients who have completed their course of radiation treatment from Sept 2022 to March 2025, there is no direct involvement from participants and no treatment is given to patients. The study will only use be using the existing radiation treatment plans and replanning them with different approaches/ parameters, then observing the correlation between plan complexity (monitor units) and physics plan quality assurance (QA) results. These different approaches/ parameters and therefore factors which will be investigated include number of lesions, shape and size of lesions, distance the lesions are from isocentre, proximity to healthy organs and whether additional optimisation structures were utilised.
Sponsors
Helen Truong - Canberra Health Services
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Age: 18 years and older. Diagnosis: intact brain metastases and/or post-operative cavities after resection of brain metastatic disease. Patients planned with HyperArc and treated on the stereotactic linear accelerator at Canberra Region Cancer Centre from Sept 2022 to March 2025.
Exclusion criteria
Nil.
Outcome results
None listed