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Effect of Energy-Restricted Mediterranean Diet on Telomere Length in overweight and obese Individuals

The Impact of an Energy-Restricted Mediterranean Diet on Telomere Length in Overweight and Obese Individuals

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12625000207415
Enrollment
28
Registered
2025-02-21
Start date
2021-02-15
Completion date
2022-02-23
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study investigates the effects of an energy-restricted Mediterranean diet on telomeres in overweight and obese individuals. It includes female participants aged 20-50 at Gazi University, Türkiye, over an eight-week period. Data on demographics, dietary records, body composition, anthropometric measurements, and physical activity levels are collected. The Mediterranean Adequacy Index (MAI) is calculated at the beginning and end of the study. Participants follow an individualized energy-restricted Mediterranean diet. Biochemical parameters such as glucose, HDL-C, LDL-C, Total-C, C-reactive protein, TNF-a, IL-6, TAS, TOS, and telomere length are analyzed.

Interventions

Energy Restricted Mediterranean Diet is given to patients by dietician. They will be asked to consume Energy-restricted Mediterranean diet with 50-60% carbohydrates, 15-20% protein, and 25-30% fat. Diet lists were prepared by the dietician for the individuals participating in the study to consume Mediterranean diet for 8 weeks. According to personal preferences, daily planning was made as "3 main meals and 3 snacks" or "3 main meals and 2 snacks". Participants received training on the Mediterra

Energy Restricted Mediterranean Diet is given to patients by dietician. They will be asked to consume Energy-restricted Mediterranean diet with 50-60% carbohydrates, 15-20% protein, and 25-30% fat. Diet lists were prepared by the dietician for the individuals participating in the study to consume Mediterranean diet for 8 weeks. According to personal preferences, daily planning was made as "3 main meals and 3 snacks" or "3 main meals and 2 snacks". Participants received training on the Mediterranean diet pyramid and recommendations for weekly and daily food group consumption. Diets were organized to ensure a Mediterranean diet score of at least 11 according to "Stefler D, Malyutina S, Kubinova R, Pajak A, Peasey A, Pikhart H, et al. Mediterranean diet score and total and cardiovascular mortality in Eastern Europe: the HAPIEE study. Eur J Nutr. 2017;56(1):421–9. ". The duration of the intervention is 8 weeks. The administration of the diet is done by dietician by face to face consultation. To assess the dietary adherence and body weight loss of the overweight and obese group, the researcher conducted biweekly interviews, monitored their body weight and composition, and engaged in weekly phone calls to evaluate their compliance with the diet and provide motivation. The dietitian assessed the individuals face-to-face with approximately half-hour interviews once every 15 days for 8 weeks. Telephone calls for evaluation and motivational purposes are approximately 15 minutes per week.

Sponsors

Gazi University Scientific Research Projects Unit (BAP)
Lead SponsorUniversity

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years
Healthy volunteers
No

Inclusion criteria

Female participants between aged 20-50, with a BMI between 25-29.9 kg/m2(overweight group) (n=14), greater than 30 kg/m2(obese group) (n=14), and who applied to the Nutrition and Dietetics Clinic of Gazi University, Faculty of Health Sciences, Department of Nutrition and Dietetics, were included in the study.

Exclusion criteria

smoking, chronic diseases except for hyperlipidemia and hypertension, males, pregnant females, breastfeeding females, heavy exercisers, vitamin-mineral supplements or nutritional supplement users, and having another special diet.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026