Almond protein powder and hydration responses in postmenopausal women.

Conditions

None listed

Brief summary

This study’s importance is drawn primarily from its focus on an under-represented demographic, which presents distinct and unique health needs. Postmenopausal women, as any other specific population, require tailored interventions to address physiological issues of importance. Assessing the efficacy of APP supplementation to induce favourable protein metabolism and hydration outcomes can advance scientific knowledge, as well as contributing to developing targeted strategies for health adaptations. Further to this, the findings of this study may offer insights of practical importance to practitioners working with postmenopausal women. Specifically, these results could inform public health programs that seek to improve the health and quality of life of postmenopausal women.

Charles Urwin, Vy Tran, Michael Tieland, Sze‐Yen Tan, Jackson Fyfe et al. (15 authors)

Frontiers in Nutrition2026-07-28

10.3389/fnut.2026.1918989

Acute effects of almond milk vs. almond milk supplemented with almond protein powder or whey protein on plasma amino acid profiles and hydration status in postmenopausal women: a randomised crossover study protocol.

Tran V, Tieland M, Tan S, Fyfe J, Feros SA, Snipe R, Allsopp G, Bruce CR, Kowalski GM, Mason S, Carr AJ, Abbott G, Hamilton LD, Huschtscha Z, Urwin CS.

2025-10-09

10.1186/s12937-025-01226-1

Interventions

The five supplementation protocols are as follows: • Water only (500 mL) (comparator treatment) • Almond milk (500 mL) (comparator treatment) • Almond protein powder (28g protein content, topped up to 500 mL with almond milk) • Whey protein powder (28g protein content, topped up to 500 mL with almond milk) • Soy protein powder (28g protein content, topped up to 500 mL with almond milk) o Note, all treatments excepting water will be flavoured with chocolate flavouring to mask the administered tre

The five supplementation protocols are as follows: • Water only (500 mL) (comparator treatment) • Almond milk (500 mL) (comparator treatment) • Almond protein powder (28g protein content, topped up to 500 mL with almond milk) • Whey protein powder (28g protein content, topped up to 500 mL with almond milk) • Soy protein powder (28g protein content, topped up to 500 mL with almond milk) o Note, all treatments excepting water will be flavoured with chocolate flavouring to mask the administered treatment. Each treatment is consumed once only, in a cross-over format. Washout between sessions is to be a minimum of two whole days. Participants will be asked to arrive having completed an overnight fast (minimum 8 hours, excepting water intake which is to be recorded and replicated). Adherence to the interventions themselves will be verified by the research team on hand during that session.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

50 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

• Biological females. • Have undergone natural menopause; no menstrual bleeds for 12 consecutive months. • Weight stable (no more than +/-2 kgs of weight change in last 2 months). • Continuously using or not using hormone therapy for more than 12 months.

Exclusion criteria

Allergy to nuts. Non-controlled high-blood pressure. History of myopathic, neuropathic, skeletal, thrombotic, or cardiovascular disorders. Any thyroid disorder (treated or untreated). Anticipated absence for more than 1 week during the study period. Current smokers. Current chronic disease including cancer, diabetes, cardiovascular disease, chronic liver disease, and gastrointestinal disorders that affects nutrient absorption. Following a vegan diet.

Outcome results