None listed
Conditions
Brief summary
Thiopental is one of the oldest hypnotic agents used in anesthetic practice. However, alone it cannot provide adequate conditions for successful LMA insertion. For this purpose, many agents have been used as adjuvants to thiopental. The aim was to compare the effect of remifentanil or dexmedetomidine administration on LMA insertion conditions before induction with thiopental in a prospective, randomized, double-blind study. In our study, 2 µg.kg -1 remifentanil administration before induction
Interventions
The study included 80 patients between the ages of 18 and 65 who were in I-II group according to the American Society of Anaesthesiologists physiological classification, who would undergo elective surgery, who did not require muscle relaxation, whose operation time did not exceed 2 hours and who had indications for laryngeal mask airway (LMA) insertion. Standard monitoring [heart rate (HR), systolic arterial pressure (SBP), diastolic arterial pressure (DBP), mean arterial pressure (MAP), electro
The study included 80 patients between the ages of 18 and 65 who were in I-II group according to the American Society of Anaesthesiologists physiological classification, who would undergo elective surgery, who did not require muscle relaxation, whose operation time did not exceed 2 hours and who had indications for laryngeal mask airway (LMA) insertion. Standard monitoring [heart rate (HR), systolic arterial pressure (SBP), diastolic arterial pressure (DBP), mean arterial pressure (MAP), electrocardiography (ECG-Derivation II), peripheral oxygen saturation (SpO 2 )] was performed before induction of anesthesia. The depth of anesthesia was monitored using bispectral index [BIS-Vista™ (Aspect Medical Systems; Newton; MA, USA)] monitoring. An intravenous line was opened with a 20 G cannula through the dorsum of the hand and 7 ml.kg -1 saline infusion was administered. Patients were randomly assigned to 2 groups (Group D and Group R n=40 in each group) to receive 1 µg.kg -1 dexmedetomidine or 2 µg.kg -1 remifentanil using the closed envelope procedure. Coded test syringes were prepared by an independent anesthesiologist with 0.9% saline in a total volume of 50 mL and 20 mL, respectively. Injection of all syringes was performed by an assistant behind a drape to blind the anesthetist to the drug doses during LMA insertion and monitoring of parameters. Preparation and administration of drugs, insertion of the LMA and monitoring of parameters were performed by different anesthetists. Medical parameters were recorded. In this way, the anesthetist who placed the LMA, monitored the patient response to the LMA, and monitored and recorded the parameters was blinded to the administered drugs.
Sponsors
Istanbul Training and Research Hospital, Department of Anesthesiology and Reanimation, Istanbul, Turkey
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
The study included 80 patients between the ages of 18 and 65 who were in I-II group according to the ASA physiological classification, who would undergo elective surgery, who did not require muscle relaxation, whose operation time did not exceed 2 hours and who had indications for LMA insertion.
Exclusion criteria
Patients with any neck and upper respiratory tract pathology, difficult airway history and probability (Mallampati class 3-4, sternomental distance below 12 cm, thyromental distance below 6 cm, head extension below 90 degrees, mouth opening below 1.5 cm), with morbid obesity, history of pulmonary disease, history of allergy to study drugs, history of alcohol and substance abuse, history of chronic sedative and opioid analgesic use, sore throat, dysphagia, and dysphonia were excluded.
Outcome results
None listed