Regenerating lost jaw bone using patient specific 3D-printed resorbable polycaprolactone mesh versus a resorbable collagen membrane

The trial compare effectiveness of the using a 3D printed patient specific polycaprolactone (PCL) (test) mesh versus a collagen membrane (control) when combined with a a composite graft composed of particulate anorganic porcine bone mineral (APBM) and autogenous bone (AB) in a 1:1 ratio for alveolar ridge augmentation (replacing lost jaw bone). What occurs during these interventions: There are two surgical interventions. The first is alveolar ridge augmentation, which is performed to reconstruct the lost jaw bone required for dental implant placement. This surgery will be performed by experienced specialist clinicians (Periodontists) with more than 17 years experience in complex alveolar bone reconstructive surgery. The procedure involves achieving access to the bone defect via a mucoperiosteal flap. Autogenous bone harvesting is performed from the retro-molar region and mixed with porcine bone mineral then loaded into the defect and covered using a patient specific 3D printed polymer (PCL) scaffold (test group) or a collagen membrane (control). This is secured to the jaw bone then covered by the flap. Surgery will be performed in a private practice and will be 90-120min in duration. The second intervention takes place 8 months later, and takes approximately 1 hour to complete. It involves elevating a mucoperiosteal flap then creating an osteotomy of specific dimensions to allow the placement of the dental implant. The flap is then replaced and allowed to heal for a further 12 weeks before the patient continues the prosthetic phase of treatment with their referring clinicians independent of the study. Adherence to intervention will be assessed by reviewing completed case report forms (CRFs).