None listed
Conditions
Brief summary
This will be a pilot trial assessing the feasibility, safety and efficacy of combined high-intensity interval training (C-HIIT) for people with disorders of gut-brain interaction (DGBI). Participants will be recruited from the local Newcastle and Hunter region district (NSW). After consent is provided, participants will undergo testing (including cardiopulmonary exercise testing, body composition, bloods, stool sample, functional strength and a series of questionnaires to capture mental health, gastrointestinal symptoms, overall wellbeing and dietary habits) and then be asked to maintain current dietary and physical activity habits for 8-weeks and then come in to repeat the testing in week 9. Following this, participants will undergo 8- weeks of 3 x weekly, 30-minute C-HIIT sessions, supervised by an accredited exercise physiologist or exercise science student. Participants will then repeat the same testing and will be invited to participate in an interview to better understand their experience with the program.
Interventions
Participants will exercise (supervised by an accredited exercise physiologist or exercise scientist student) for 26 minutes three times per week, for an exercise duration of 78 minutes/week, over the course of 8 weeks. Sessions will be either one on one, or in a small group, depending on time and day preference, and or participant requests. Each session will begin with an aerobic warm-up for three minutes at 50-60% heart rate peak (HRpeak) (determined from the peak heart rate achieved during the
Participants will exercise (supervised by an accredited exercise physiologist or exercise scientist student) for 26 minutes three times per week, for an exercise duration of 78 minutes/week, over the course of 8 weeks. Sessions will be either one on one, or in a small group, depending on time and day preference, and or participant requests. Each session will begin with an aerobic warm-up for three minutes at 50-60% heart rate peak (HRpeak) (determined from the peak heart rate achieved during the cardiopulmonary exercise test) before completing four minutes of high-intensity aerobic exercise at 85-95% of HRpeak. The goal is to reach the target zone within the first two minutes. Following one minute of rest, participants will complete 8 x 1-minute intervals of high-intensity resistance exercise at a rate of perceived exertion (RPE) of greater than or equal to 8 (very hard). This will be monitored throughout, and an RPE of 7 will incur that the weights for that exercise need to be increased. Exercises include functional exercises such as squats, push-ups and lunges that can be adapted to different levels of strength and ability. Participants will complete as many repetitions (at least five; aiming for 10-25) as possible within each 1-minute bout while maintaining correct form. One minute of rest will separate each interval. The session will end with an aerobic cool-down for three minutes at 50-60% of HRpeak. Each completed session will be marked off as attended and the RPE average will be calculated to assess adherence.
Sponsors
University of Newcastle
Study design
Allocation
Non-randomised trial
Primary purpose
Educational / counselling / training
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Participants will be individuals aged 18 years and over with a diagnosed disorder of gut-brain interaction (DGBI) such as irritable bowel syndrome (IBS) or functional dyspepsia (FD). DGBI diagnosis may be confirmed using the Rome IV criteria, which includes recurrent abdominal pain on average at least one day per week in the last three months, associated with two or more of the following: 1) related to defecation, 2) associated with a change in frequency of stool, 3) associated with a change in form (appearance) of stool. Decisions on inclusion will be made in collaboration with the study Doctor.
Exclusion criteria
People will be ineligible if they: have an organic gastrointestinal disorder (e.g., inflammatory bowel disease, colorectal cancer or coeliac disease), are experiencing ‘alarm’ signs or symptoms (e.g., gastrointestinal bleeding, iron deficiency anaemia, significant unexplained weight loss), have any condition as per the absolute contraindications to exercise outlined by the American College of Sports Medicine (ACSM, 2021) including, but not limited to: unstable angina; recent (within the past four weeks) myocardial infarction; coronary artery disease; uncompensated heart failure; New York Heart Association functional classification II-IV; severe valvular illness; pulmonary disease; uncontrolled hypertension (systolic blood pressure > 200 mmHg and/or diastolic blood pressure > 110 mmHg); renal failure (chronic kidney disease stages IV-V); cardiomyopathy. People will also be ineligible for: meeting the physical activity guidelines (150minutes/week moderate intensity or 75minutes/week vigorous intensity exercise), due to planned medical operations during the research period, a physical condition whereby exercise training would be inappropriate, pregnant or expecting to be pregnant during the study period, and non-English speaking.
Outcome results
None listed