None listed
Conditions
Brief summary
In this prospective observational study, adult participants undergoing total or partial unilateral nephrectomy are assessed preoperatively and postoperatively (1 and 3 months after the surgery) by a kidney functional reserve (KFR) test .Preoperative KFR and postoperative loss of KFR will be assessed as predictors of long-term kidney function and damage as assessed by serum creatinine and albuminuria within 1 year after the surgery. The hypothesis is that a lower preoperative kidney functional reserve and/or a bigger loss of kidney reserve after the surgery will identify people at higher risk of developing worsening kidney function at long-term (i.e.: 1 after the surgery).
Interventions
No intervention.
Exposure is the need of total or partial unilateral nephrectomy surgery due to kidney donation, removal of kidney cancer or kidney auto-transplantation.
- what is involved for patients in this study: Recruited patients will have blood and urine samples collected before and after kidney surgery, for kidney biomarkers measurement. Pre and postoperative assessments include an oral protein shake to allow for evaluation of the kidney functional reserve before the surgery, 1 month aft
No intervention. Exposure is the need of total or partial unilateral nephrectomy surgery due to kidney donation, removal of kidney cancer or kidney auto-transplantation. - what is involved for patients in this study: Recruited patients will have blood and urine samples collected before and after kidney surgery, for kidney biomarkers measurement. Pre and postoperative assessments include an oral protein shake to allow for evaluation of the kidney functional reserve before the surgery, 1 month after the surgery and 3 months after the surgery. Clinical data will be collected from medical records and from the patients. - what is being observed in participants: postoperative change of kidney function within 1 year after the surgery, change in kidney functional reserve at 1 and 3 months after the surgery, change in albuminuria 1 year after the surgery. - the anticipated time required to complete each assessment is: preoperative kidney functional reserve test for participants who agree to do it: 6 hours, each time, for 3 times: before the surgery, 1 month after the surgery and 3 months after the surgery. - the overall duration of observation: from time of enrollment for 1 year.
Sponsors
Professor Zoltan Endre, Nephrology Department at Prince of Wales Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adult patients undergoing total or partial unilateral nephrectomy due to kidney donation, kidney cancer removal or kidney auto-transplantation.
Exclusion criteria
1. History of malabsorption or chronic inflammatory bowel disease or short bowel syndrome (precluding preoperative assessment using a protein load) 2. History of pancreatic insufficiency (precluding preoperative assessment using a protein load) 3. History of kidney transplantation
Outcome results
None listed