None listed
Conditions
Brief summary
Chronic ischemic heart disease (IHD) is a major health issue in many developed countries, including New Zealand, where one in 20 adults has heart disease. Thanks to better treatments, more people are living with chronic IHD. However, it's still hard to predict when their condition might suddenly get worse. While advanced tests can help monitor the disease, they are expensive and require visits to specialized centers. Therefore, we need a simpler and more accessible way to check heart health. MicroRNAs (miRNAs), small molecules in the blood, show promise as they are stable and linked to heart disease. This study aimed to find out if changes in miRNA levels can indicate heart function and help predict disease progression and treatment outcomes in IHD patients.
Interventions
The study was designed to measure the changes in the expression level of circulating microRNAs with the progression of ischemic heart disease (IHD) and to correlate its expression levels with cardiac function. For this reason, participants who were newly diagnosed with IHD were recruited. Following informed consent and general health questionnaire which is expected to take 15 minutes to complete, blood samples were collected and echocardiography was performed to measure cardiac function. Partici
The study was designed to measure the changes in the expression level of circulating microRNAs with the progression of ischemic heart disease (IHD) and to correlate its expression levels with cardiac function. For this reason, participants who were newly diagnosed with IHD were recruited. Following informed consent and general health questionnaire which is expected to take 15 minutes to complete, blood samples were collected and echocardiography was performed to measure cardiac function. Participants were re-invited at 6, 12, 24, 36, 48 and 60 months for collection of blood samples and echocardiography measurement.
Sponsors
University of Otago
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Diabetic or non-diabetic newly diagnosed with ischemic heart disease. 2. Age 20 – 80 years of both genders
Exclusion criteria
1. History of acute myocardial infarction 2. History of valvular disease. 3. Aged >80 years and < 20 years 4. Recent major surgery 5. Diagnosed with cancer
Outcome results
None listed