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Optical coherence tomography imaging of the back of the eyes of healthy participants to develop automated measurement software

Swept source optical coherence tomography angiography imaging of the posterior eye of participants with healthy eyes to develop automated segmentation software

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12625000013460
Enrollment
40
Registered
2025-01-09
Start date
2025-01-22
Completion date
2025-04-12
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Swept source optical coherence tomographers (SS-OCTs) provide high resolution images of the eye and have an enhanced depth of focus (greater scanning depth in tissue) compared to conventional (spectral domain) OCTs. These additional features allow for blood flow characteristics in the retina and choroid to be quantified (OCT Angiography) without the use of any additional dyes, drugs or contact with the eye. This is a prospective data collection study which aims to capture clinical data of the choroid with the Triton swept source OCT including angiography. In order to enhance the vascular characteristics analysis, software tools will later be developed by the project team.

Interventions

The choroid and layers of the posterior eye will be imaged using the Triton swept source OCT angiography instrument in participants with healthy eyes to allow development of automated segmentation software. The software delineates the thickness of individual tissue layers in the eye. The software can be later used in the development of myopia interventions to slow eye growth. The images provide a cross section of the eye tissues. The scanning protocols to be used include: • Horizontal line scan

The choroid and layers of the posterior eye will be imaged using the Triton swept source OCT angiography instrument in participants with healthy eyes to allow development of automated segmentation software. The software delineates the thickness of individual tissue layers in the eye. The software can be later used in the development of myopia interventions to slow eye growth. The images provide a cross section of the eye tissues. The scanning protocols to be used include: • Horizontal line scans (9 mm width) – 6 times • Five-line cross scan (6 mm width) – 6 times • Radial scan pattern (6 mm width) – 6 times • Angiography scans – 3D Macula (3 mm volumetric) – 6 times A typical scanning protocol involves: • Adjusting the participant’s head/eye position in the Triton headrest until they can see the Triton’s internal fixation target • Instructing the participant to continue watching the fixation target during the scans and the likely length of the scan time • Instructing the participant to blink twice and then waiting 2-3 seconds before the scan commences to ensure a high-quality tear distribution and optimal scan quality • Instructing the participant to sit back from the instrument and relax before commencing the next set of scans The scanning protocol typically requires a few minutes per scan and there are four different scanning protocols. There will be a single visit with total duration of about 60 minutes.

Sponsors

Queensland University of Technology
Lead SponsorUniversity

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

Good vision Healthy eyes

Exclusion criteria

The presence of cataracts will interfere with the optical coherence tomography scans and participants with cataracts will be excluded.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026