Self-Collection or Practitioner-collection Evaluation 3 to compare the clinical performance of detecting HPV associated with cervical disease

The study will ask participants to take two self-collected samples, one using a swab to collect a vaginal sample, and the other being a urine sample, and compare them against the standard of care clinician-collected specimen from the cervix for the detection of Human Papillomavirus (HPV) using any colposcopy biopsy findings as the reference for sensitivity and specificity for cervical disease. Participants who have been referred to colposcopy would not be routinely tested for HPV as this is a risk stratification rather than diagnostic test. The two devices are the Abbott simpli-COLLECT kit and the Novosanis Colli-pee device. The simpli-COLLECT swab is identical to swabs used for self-collection of vaginal samples for testing for sexually transmitted infections. The Colli-pee is a device which allows the collection of a specific volume of the first pass urine and has been validated for self-collection of urine for HPV testing in other studies. Both self-collection samples will be collected at the same time in a private space while waiting for the patient's colposcopy appointment, Collection with both devices would be completed is less than five minutes total time . Adherence to correct use of either the Colli-pee or simpli-COLLLECT devices will be determined by the presence of clinical material. The collection of urine into the Colli-pee will be visible by the increase in volume in the device. The Abbott Alinity m HPV assay will also detected whether sufficient human cellular material is present to determine if a valid clincal sample has been collected. Valid sample rates for both devices will be assessed and reported.