None listed
Conditions
Brief summary
The comorbidity of BPD with SUD is frequently observed in clinical practice and has significant implications for both symptomatology and treatment. These two disorders not only share certain etiological factors—such as impulsivity, a history of trauma, and common genetic vulnerabilities—but the onset of one disorder may trigger and promote the chronicity of the other, leading to further deterioration in overall functioning. To better understand these conditions and improve therapeutic management, it is essential to conduct a detailed analysis that goes beyond current symptomatology, considering potential comorbidities, impulsivity, and the patient’s personal history for evidence of childhood trauma. Identifying BPD-related variables most strongly associated with a higher likelihood of developing SUD could enable the implementation of early intervention strategies, reducing the impact of both conditions on overall functioning and allowing for a more tailored rehabilitative and pharmacological approach. Recognizing personality disorder patients at high risk for SUD could facilitate timely support through addiction services, potentially preventing further impairment in global functioning due to comorbidity.
Interventions
No experimental pharmacological treatment is planned.
No experimental device is included.
The study involves the patient participating in a clinical interview to assess inclusion and exclusion criteria, followed by an interview to introduce the project. After completing the medical history collection, psychometric scales will be administered to evaluate core symptoms of the disorder, aggressiveness, anxiety and depressive symptoms, borderline symptomatology, substance use disorder symptomatolog
No experimental pharmacological treatment is planned. No experimental device is included. The study involves the patient participating in a clinical interview to assess inclusion and exclusion criteria, followed by an interview to introduce the project. After completing the medical history collection, psychometric scales will be administered to evaluate core symptoms of the disorder, aggressiveness, anxiety and depressive symptoms, borderline symptomatology, substance use disorder symptomatology, quality of life, and overall functioning. An initial outpatient interview will be scheduled to present the project and evaluate the aforementioned parameters, lasting approximately 60 minutes. Subsequent outpatient sessions will then be arranged for the administration of various psychometric scales, with each session lasting approximately 100 minutes (approximately 10 minutes per test - psychometric scale). Clinical data will be collected using specific psychometric scales, including Initial outpatient interview (60 minutes) MCMI-III – Millon Clinical Multiaxial Inventory III (10 minutes) SCID-5 – Structured Clinical Interview for DSM-5 Personality Disorders (30 minutes) Subsequent outpatient session (100 minutes) BPDSI – Borderline Personality Disorder Severity Index (10 minutes) BIS-11 – Barratt Impulsivity Scale (10 minutes) TAS-20 – Toronto Alexithymia Scale – 20 (10 minutes) CISS – Coping Inventory for Stressful Situations (10 minutes) CTQ-SF – Childhood Trauma Questionnaire – Short Form (10 minutes) ABQ – Addictive Behavior Questionnaire (10 minutes) SAT-P – Satisfaction Profile (10 minutes) SOFAS – Social and Occupational Functioning Assessment Scale (10 minutes). The assessment through testing will be conducted in a single session. This session will be preceded by an introductory meeting to analyze inclusion and exclusion criteria (including the verification of the BPD diagnosis using MCMI-III and SCID-5) and to present the project. Case Group: consecutive outpatients (ages 18-60) diagnosed with Borderline Personality Disorder and Substance Use Disorder according to DSM-5 criteria.
Sponsors
University of Turin (UniTo)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Case: Consecutive outpatients (ages 18-60) diagnosed with BPD and SUD according to DSM-5 criteria will be recruited. The diagnosis will be made through evaluation by experienced clinicians and administration of the SCID-5 (Structured Clinical Interview for DSM-5 Personality Disorders). Controls: Consecutive outpatients (ages 18-60) diagnosed with BPD according to DSM-5 criteria will be recruited. Diagnosis will be conducted through evaluation by experienced clinicians and administration of the SCID-5 (Structured Clinical Interview for DSM-5 Personality Disorders).
Exclusion criteria
Cases: a) Presence of neuropsychiatric comorbidities, including: neurodevelopmental disorders; neurocognitive disorders; schizophrenia and schizophrenia spectrum disorders; bipolar disorder; b) Concurrent major depressive episode; c) Symptomatic severity assessed by the clinician as incompatible with the administration of psychometric tests. Controls: a) Presence of neuropsychiatric comorbidities, assessed according to DSM-5 criteria and including: neurodevelopmental disorders; neurocognitive disorders; schizophrenia and schizophrenia spectrum disorders; bipolar disorder; b) Concurrent major depressive episode; c) Current or past use of alcohol and substances; d) Symptomatic severity incompatible with the administration of psychometric assessments.
Outcome results
None listed