None listed
Conditions
Brief summary
The purpose of this study is to investigate if a single bout of resistance exercise can acutely reduce tumour hypoxia in prostate cancer patients who are scheduled to receive external beam radiation therapy. Who is it for? You may be eligible to join this study if you are a male aged 18 years or over, have a diagnosis of localised or locally advanced prostate cancer, and are scheduled to receive conventional or hypofractionated external beam radiation therapy in the Perth metropolitan area. Study details: Participants in this study will attend a single supervised exercise session before starting their radiation therapy treatment. The study intervention involves performing resistance exercises at a medical research facility. Specifically, the exercise session is 20 minutes in duration and takes place at the Harry Perkins Institute of Medical Research, where you will also have an MRI scan immediately before and after the exercise session to measure tumour blood flow and tumour oxygen levels. All participants will also complete a baseline assessments at the Exercise Medicine Research Institute (Edith Cowan University) to evaluate their physical activity levels, aerobic fitness and muscle strength. It is hoped this research will contribute to new knowledge that will help improve treatment outcomes and survivorship care for prostate cancer patients by demonstrating the benefits of engaging in physical exercise while undergoing external beam radiation therapy.
Interventions
Participants will attend a single session of resistance exercise (also known as resistance training or strength training) before starting their treatment with external beam radiation therapy; specifically, the exercise session will be performed within 7 days prior to radiation therapy commencement. The exercise session/intervention will be individually supervised by an appropriately qualified exercise professional (e.g., an Exercise and Sports Science Australia [ESSA] accredited exercise physiol
Participants will attend a single session of resistance exercise (also known as resistance training or strength training) before starting their treatment with external beam radiation therapy; specifically, the exercise session will be performed within 7 days prior to radiation therapy commencement. The exercise session/intervention will be individually supervised by an appropriately qualified exercise professional (e.g., an Exercise and Sports Science Australia [ESSA] accredited exercise physiologist) and will be delivered face to face (in person). The exercise session will comprise 20 minutes of resistance training targeting the major upper- and lower-body muscle groups and will be performed at moderate to vigorous intensity. Resistance training will include 4-5 exercises that involve the major upper- and lower-body muscle groups, including squats, calf raises, deadlifts, and step ups (or appropriate alternatives depending on participant constitution and ability). Each resistance exercise will be performed for 2-3 sets at a load of 8-12 repetitions per set (i.e., the maximum load with which 8-12 repetitions can be performed with correct form, approximately 75% 1RM). The exercise intervention will be delivered at a medical research facility in the Perth metropolitan area. Intervention adherence will be assessed by the supervising exercise physiologist by recording the amount of completed exercise (i.e., duration, intensity, and volume).
Sponsors
Edith Cowan University
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator)
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
I) Patients diagnosed with localised or locally advanced prostate cancer; II) Patients scheduled for conventional or hypofractionated external beam radiotherapy; and III) Approval from treating oncologist to participate in study.
Exclusion criteria
I) Previous radical prostatectomy; II) Patients already engaging in regular exercise (defined as undertaking structured, i.e. planned and individualised, aerobic or resistance exercise on 2 or more days per week within the past 3 months); III) Acute illness or musculoskeletal/ cardiovascular/ neurological disorder that could put patients at risk during exercise testing or training; IV) Bone metastases; and V) Contraindication to magnetic resonance imaging.
Outcome results
None listed