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Lactation Intensity and reduction in the prevalence of metabolic syndrome after a maternal complication of pregnancy: an observational cohort analysis

Lactation Intensity and reduction in the prevalence of metabolic syndrome after a maternal complication of pregnancy: an observational cohort analysis in women with a previous pregnancy complication.

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12624001351505
Enrollment
91
Registered
2024-11-08
Start date
2023-09-01
Completion date
2026-04-01
Last updated
2024-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Major pregnancy complications such as preeclampsia and gestational diabetes mellitus are associated with development of type II diabetes mellitus and coronary heart disease, which are becoming ever more prevalent in young women. Despite clinical recommendations to optimise cardiovascular disease (CVD) risk factors after a complication of pregnancy, tailored lifestyle programs have poor adherence and are not suited to the lifestyle of a mother during the early postpartum period. Breastfeeding (lactation) is associated with a reduction in hypertension and diabetes later in life, however there has not been a direct focus on elucidating how breastfeeding affects certain components of cardiometabolic health in women with a previous pregnancy complication within the early postpartum period. We hypothesize that those who have a higher lactation intensity over 6 months postpartum (>=0.8 intensity score) will have a lower risk of metabolic syndrome at 6 months postpartum following a major pregnancy complication. This project aims to determine if lactation intensity is associated with a reduction in the rate of metabolic syndrome at 6 months postpartum in women with a maternal complication of pregnancy.

Interventions

Eligible women who are referred to COFFEE (Cardiovascular Assessment After Obstetric Complications: Follow-Up For Education and Evaluation) clinic are included in this study. COFFEE clinic is a postpartum cardiovascular preventative service at the Lyell McEwin Hospital for women with previous complications of pregnancy. They are routinely assessed by a cardiac nurse practitioner at 6 months, 18 months and 5 years post-pregnancy for cardiovascular disease risk and primary prevention through lifes

Eligible women who are referred to COFFEE (Cardiovascular Assessment After Obstetric Complications: Follow-Up For Education and Evaluation) clinic are included in this study. COFFEE clinic is a postpartum cardiovascular preventative service at the Lyell McEwin Hospital for women with previous complications of pregnancy. They are routinely assessed by a cardiac nurse practitioner at 6 months, 18 months and 5 years post-pregnancy for cardiovascular disease risk and primary prevention through lifestyle modification. Women at the time of their antenatal discharge will be contacted by the researcher either at time of discharge or within 5 weeks of discharge via telephone to participate in the study. Upon informed consent and enrollment to the study, participants will be asked to complete short, online questionnaires once a month on breastfeeding difficulties, and infant feeding patterns. They will complete 1 questionnaire a month for the period of 6 months. Data from their COFFEE clinic postpartum appointment at 6 months will be collected to assess cardio-metabolic risk factors including weight, blood pressure and biochemical markers.

Sponsors

University of Adelaide
Lead SponsorUniversity

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years
Healthy volunteers
No

Inclusion criteria

Women with a previous pregnancy complication who are referred to a postpartum cardiovascular preventative clinic at 6 months postpartum: • Hypertensive disorders of pregnancy (including gestational hypertension, preeclampsia, eeclampsia and HELLP syndrome), requiring medical therapy or resulting in <37 weeks’ gestation; • Gestational diabetes mellitus requiring metformin or insulin therapy; • Preterm delivery at <35 weeks’ gestation; • Delivery of a small for gestational age infant; • Placental abruption

Exclusion criteria

• Patients without ability to provide informed consent • Patients <18 years of age

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026