None listed
Conditions
Brief summary
The purpose of this study is to test the acute response to different foods that vary in their level of processing or formulation. Our main outcomes is the acute glycaemic response to each of these foods, as it is one cardiometabolic indicator of health for adults diagnosed with T2 diabetes. With these tests we will see if food processing, formulation, or both processing and formulation influence acute blood glucose control in a predictable manner that might enable better nutrition communication about what people with type 2 diabetes should eat. We hypothesise that the different processing techniques and different added ingredients will change the blood glucose response to each food but not in a consistent manner that allows use of simplified nutrition messages such as 'food processing worsens blood glucose response' or 'food formulation worsens blood glucose response'.
Interventions
Dietary interventions: single meal responses to 16 different foods and three glucose standards on 19 different mornings. Each of the foods vary in food type, processing, and formulation, but all contain 25g of available carbohydrate (sugars and starch). The three glucose drink interventions are all the same exposure and also provide 25g of available carbohydrate. The average of the three glucose exposures is used as a way to account for within-person variability in how they respond day-to-day. Foods and glucose drinks are tested inline with the ISO standard for postprandial blood glucose testing. Each intervention is started in the morning with a fasted participant who has 10 minutes to consume the food and three hours sitting in a chair while their capillary blood glucose is measured. Blood glucose measurements are taken from fingers at baseline, then at 15, 30, 45, 60, 90, 120, 150, and 180 minutes. This morning process is conducted under observation. Participants are free to pursue their interests of this three hours, but are required to remain largely sedentary in a chair. The foods being tested are 1) Oranges (225g) either as whole fruit (with and without added fibre, or orange juice (with and without added fibre. 2) Legumes (200g) (cooked plain or with olive oil) or freeze dried cooked legumes (plain or with olive oil). 3) Cow milk (450g, plain or with added protein) or yoghurt made from cow milk (plain or with added protein). 4) Cooked oats (100-170g) either intact (with or without sugar) or milled (with or without sugar). The amount of oats served per morning varies, as the added sugar counts towards the 25g available carbohydrate that determines serve size. Participants will be asked to eat all interventions of that food type (i.e. the oranges), before being asked if they wish to continue to test the next food type (i.e. oats).
Sponsors
Study design
Eligibility
Inclusion criteria
Participants will be adults 18-75 years diagnosed with type 2 diabetes mellitus. Antihyperglycaemic drug use is permitted, provided a medical professional has not changed dose or type in the last three months. Regular insulin use of the same dose is also permitted, but basal bolus insulin use (changing amount in response to a meal). Presence of comorbidities will not exclude participation.
Exclusion criteria
Current pregnancy, lactation, allergies or intolerance to the test foods, and inability or unwillingness to comply with the intervention requirements will exclude participation.