None listed
Conditions
Brief summary
Primary Sclerosing Cholangitis (PSC) is a rare and chronic liver disease with no proven effective medical therapies to prevent disease progression. Most patients with PSC have ulcerative colitis (UC), with potential overlapping pathophysiological mechanisms including an abnormal gut microbiota. Diet is a key fertiliser of the gut microbiota and limited evidence suggests diet may have a role is disease pathogenesis. However, there is very limited international data on the habitual diet and diet quality of adults and adolescents with PSC to inform dietary treatment targets. Therefore, this cross-sectional study will comprehensively evaluate the dietary patterns of people with PSC and understand how people who live with PSC perceive diet in disease development and progression as a first step toward informing further dietary interventions.
Interventions
Primary sclerosing cholangitis (PSC), is a rare autoimmune liver disease with no effective medical therapies. The aetiology and pathogenesis of PSC are unknown, however, evolving evidence suggests dysbiosis of the gut microbiota may be a contributing factor. Diet is a key fertiliser of gut microbiota and therefore has potential to be a modifiable risk factor. However, very limited data on dietary patterns and trends of people with PSC exist
This is an observational study of habitual dietary inta
Primary sclerosing cholangitis (PSC), is a rare autoimmune liver disease with no effective medical therapies. The aetiology and pathogenesis of PSC are unknown, however, evolving evidence suggests dysbiosis of the gut microbiota may be a contributing factor. Diet is a key fertiliser of gut microbiota and therefore has potential to be a modifiable risk factor. However, very limited data on dietary patterns and trends of people with PSC exist This is an observational study of habitual dietary intake where participants will be asked to complete online questionnaires and a food frequency questionnaire to observe habitual dietary patterns and the dietary perceptions and food beliefs that inform dietary behaviour and food choice. This will occur at a single timepoint and the online questionnaires are expected to take 20-30 minutes to complete
Sponsors
The Queen Elizabeth Hospital, Central Adelaide Local Health Network
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adolescents and adults (equal to or greater than 16 years old) with a diagnosis of PSC self-confirmed via imaging and biochemical markers will be invited to participate in this study
Exclusion criteria
Exclusion criteria are those unable to read and interpret English.
Outcome results
None listed