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Clinical Outcomes following Acute Shock in Trauma - The Sydney COAST Study

Prospective observational study assessing patient characteristics, clinical management, and short-term outcomes of major trauma patients with prehospital shock and hypotension.

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12624001202550
Acronym
Sydney COAST Study
Enrollment
330
Registered
2024-10-01
Start date
2025-01-01
Completion date
2029-12-31
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The Sydney COAST study will create a clinician-defined, meaningful dataset containing both prehospital and in-hospital data. The study will examine this for the identification of physiological, mechanistic, or biochemical risk factors that influence in-hospital mortality for major trauma patients with shock, across the greater Sydney area.

Interventions

Prehospital patients with major trauma induced shock treated by specialist prehospital medical teams (critical care physician and paramedic) will undergo usual (contemporary) treatment as directed by the treating physician. There is no direct involvement for patients in this study as the entirety of their clinical care (and short term outcomes) are being directly observed. Clinical data (routinely collected data via medical records) will be collected over the first 30-days following injury

Sponsors

NSW Health
Lead SponsorGovernment body

Eligibility

Sex/Gender
All
Age
16 Years to No maximum
Healthy volunteers
No

Inclusion criteria

- Traumatic injury - Treated by NSWA-AO prehospital medical teams from Sydney, Wollongong, or Orange bases. - Age greater than or equal to 16 years - Shock (defined below) - Taken directly from scene to participating Sydney-based Major Trauma Centre. Acute shock: Any of the following; - SBP less than 100mmHg at any time during prehospital care - Shock Index >1 at any time during prehospital care - Blood transfusion (packed red blood cells or plasma) - Administration of inotropic agent

Exclusion criteria

Nil specific

Outcome results

None listed

Source: ANZCTR · Data processed: Jun 11, 2026