None listed
Conditions
Brief summary
Creatine plays a crucial role in rapidly providing energy to the brain during times of increased demand such as sleep deprivation and mental health conditions (i.e.: depression). Such energy provision is crucial considering the brain is a highly metabolically active organ and requires a constant energy supply. However, current research has only investigated the potential anti-depressant effects of creatine supplementation with traditional pharmacological interventions that are known to induce multiple health side effects and are associated with low success. Considering exercise is a well-established, efficacious treatment option for reducing depressive symptoms for individuals with depression, this proposal will test the hypothesis that the synergistic effects of creatine supplementation and exercise can reuce symptoms of depression and anxiety, while concomitantly improving motivation in adults aged between 18-39 years with mild-to-moderate depression over a six-week period.
Interventions
There are two separate treatment arms:
Treatment Arm One: 10g Creatine per day for 6 weeks; oral (diluted in flavored cordial in an opaque bottle) without resistance training
Treatment Arm Two: 10g Creatine per day for 6 weeks; oral (diluted in flavored cordial in an opaque bottle) with resistance training as detailed below.
6 weeks resistance training, 3 times per week with at least 48 hours recovery; Whole-Body program
All exercise sessions will be supervised by selected research investiga
There are two separate treatment arms: Treatment Arm One: 10g Creatine per day for 6 weeks; oral (diluted in flavored cordial in an opaque bottle) without resistance training Treatment Arm Two: 10g Creatine per day for 6 weeks; oral (diluted in flavored cordial in an opaque bottle) with resistance training as detailed below. 6 weeks resistance training, 3 times per week with at least 48 hours recovery; Whole-Body program All exercise sessions will be supervised by selected research investigators that are first aid-trained and have previously completed their Certificate 3 and 4 in Fitness Sessions will be one-on-one at the Swinburne University gym Exercise intensities will range from 50-80% of a pre-determined maximum strength test and will be performed at an intensity level aiming for 7-9 out of 10 on a Borg Scale Participants will complete three sessions per week for six weeks; each session will last between 35-45 minutes including a warm-up and warm-down. Adherence will be monitored by counting the number of sessions completed during the six period and compared to the target of 18 sessions throughout the entire intervention.
Sponsors
Swinburne University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Caregiver)
Eligibility
Sex/Gender
All
Age
18 Years to 39 Years
Healthy volunteers
No
Inclusion criteria
- Aged 18-39 years. - Mild-moderate depression severity (scoring between 5-19 on the Patient Health Questionnaire-9, PHQ-9) - Body mass index (BMI) is between 18.5-29.9 kg/m². - Sedentary (less than 150 min/week exercise/ physical activity) - Not involved in a structured exercise program involving more than 2 exercise sessions per week in the last 6 months
Exclusion criteria
- Hazardous alcohol or tobacco use using the AUDIT Alcohol Screening Tool - No current or previous use of creatine supplements - Physically active (greater than 150 min/week exercise/ physical activity) - Serious somatic disorder based on a previous diagnosis from a Medical Doctor - Psychiatric treatment - Moderately severe and severe depression (PHQ-9>14 or >20 respectively). - Body mass index (BMI) above 29.9 kg/m² - Asthma - Any current or history of respiratory or cardiac conditions - Diabetes - Pre-existing renal disease or proteinuria on baseline urinalysis testing - History of creatinine hypersensitivity - Concomitant treatment with antiepileptic or antipsychotic medications - Neurological or psychiatric disorder - Clinically significant suicidal or homicidal risk
Outcome results
None listed