None listed
Conditions
Brief summary
This clinical trial aims to investigate the protective effects of tocotrienols and squalene on the skin of patients with dry skin conditions. Tocotrienols, a subgroup of vitamin E known for their strong antioxidant properties, and squalene, a colorless oil abundant in skin sebum, Alteration in tocotrienol and squalene levels in skin may contribute to dry skin conditions, and our hypothesis is that supplementing these nutrients could potentially alleviate this issue.
Interventions
There are 2 types of interventions in this study: Low Dose STGAIA and High dose STGAIA.
The supplement is administered as a single oral sachet containing Tocogaia (330 mg) and squalene (50 mg) for low dose STGAIA group and Tocogaia (330mg), squalene (50mg) twice a day for high dose STGAIA, This supplement is administered by mixing the contents of the sachet with water and taking it after a meal. Any unused sachets must be returned for proper disposal or evaluation. Patients will undergo skin, ha
There are 2 types of interventions in this study: Low Dose STGAIA and High dose STGAIA. The supplement is administered as a single oral sachet containing Tocogaia (330 mg) and squalene (50 mg) for low dose STGAIA group and Tocogaia (330mg), squalene (50mg) twice a day for high dose STGAIA, This supplement is administered by mixing the contents of the sachet with water and taking it after a meal. Any unused sachets must be returned for proper disposal or evaluation. Patients will undergo skin, hair, and nail assessments at the baseline, first visit, second visit, and third visit. For the nutrigenomic study, samples from the baseline and second visit of the High Dose STGAIA group will be utilized. Low Dose STGAIA a.(Tocogaia:330mg, squalene:50mg), b. single administration, c. oral sachet, d. once a day, e. administered and monitored under the supervision of a dermatologist, f. supplement sachet return, High Dose STGAIA a.(Tocogaia:660mg, squalene:100mg), b. double administration, c. oral sachet, d. twice a day, e. administered and monitored under the supervision of a dermatologist, f. supplement sachet return,
Sponsors
Monash University Malaysia
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver)
Eligibility
Sex/Gender
All
Age
25 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
1. Provision of a signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability to attend study visits for the duration of the study 3. English or Malay-speaking 4. Both sexes who are 25-45- years of age 5. Score of a 10 or higher in the Xerosis Area and Severity Index (XASI).
Exclusion criteria
1. Current self-reported lactation, pregnancy or active intent to conceive 2. Fever within seven days of study enrolment 3. Self-reported systemic antibiotics (oral or injectable) use in the past six weeks. 4. On treatment or medication 5. Menopause and/or taking hormone replacement therapy 6. Consuming hair, skin and nail supplements or prescribed medicine 7. Have some health-related problem (e,g, flu, fever, allergy)
Outcome results
None listed