None listed
Conditions
Brief summary
Clonal haematopoiesis of indeterminant potential (CHIP) is defined a genetic variation that leads to expansion of certain blood cells, particularly those with an immune function. CHIP is increasingly common beyond the age of 65 and associated with an increased risk of heart attack. The purpose of this study is to find out more about inflammatory processes after heart attack for CHIP positive patients compared to CHIP negative patients. We will screen for inflammatory markers and other molecular information in blood samples from people with and without CHIP who have had a recent heart attack.
Interventions
Consenting participants who have had a myocardial infarction will undergo the collection of clinical data sourced from the medical record, and blood samples will also be taken. The blood samples will be used for analysing lipids, inflammatory markers and other markers of vascular injury. The sample will also undergo genetic analysis for somatic gene mutations so that participants can be classified as having or not having clonal haematopoiesis of indeterminant potential. An additional blood sampl
Consenting participants who have had a myocardial infarction will undergo the collection of clinical data sourced from the medical record, and blood samples will also be taken. The blood samples will be used for analysing lipids, inflammatory markers and other markers of vascular injury. The sample will also undergo genetic analysis for somatic gene mutations so that participants can be classified as having or not having clonal haematopoiesis of indeterminant potential. An additional blood sample will be stored for future biomedical research in participants who content to this. Participants may be followed for additional samples or medical records may be accessed within a 5 year period. Up to two additional blood samples may be taken at any time within a 2 year period, post-myocardial infarction.
Sponsors
Monash University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age 65 years or older 2. Able to provide written, voluntary and informed consent. 3. Willing to complete all study procedures during the visit. 4. Able to undergo collection of blood specimens. 5. Diagnosis of myocardial infarction 3-12 months prior to enrolment date.
Exclusion criteria
1. Unable to complete all study procedures during the visit. 2. Not appropriate to have blood collections for clinical reasons e.g. severe anemia, poor venous access, or other. 3. Presence of uncontrolled systemic inflammatory disease 4. Use of oral corticosteroids or use of disease modifying anti-rheumatic drugs
Outcome results
None listed