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Effectiveness of educational interventions to improve the quality use of medicines in Australian general practice for people with gout and older adults prescribed antidepressants

Can co-designed, tailored and facilitated educational interventions improve general practice management of people with gout and older adults prescribed antidepressants? A pragmatic cluster randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12624000989549
Enrollment
90
Registered
2024-08-13
Start date
2024-10-30
Completion date
2025-08-21
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Improving GP care for people with gout and antidepressant prescription in older adults have been identified as priority areas for Quality Use of Medicine (QUM) programs in the Quality Use of Diagnostics, Therapeutics and Pathology (QUDTP) guidelines. The aim of this trial is to determine the effect of co-designed, tailored and facilitated educational interventions in improving the quality use of medicines in general practice for people with gout and older adults prescribed antidepressant medication. Each group will act as the other’s control. Both groups will have access to educational resources available on demand for both topics via the Medcast online education platform. The study hypothesis is that co-designed, tailored and facilitated educational interventions will be effective in improving general practice care for people with gout and older adults prescribed antidepressant medication.

Interventions

Participating general practices will be randomised to receive a co-designed, tailored and facilitated intervention (virtual educational visits and peer group learning seminars) designed to improve the provision of evidence-based care for either people with gout (Group 1) or older adults prescribed antidepressant medication (Group 2). Each group will act as the other’s control. Key messages of the program for gout will include: - Start urate-lowering therapy at a low dose - Commence flare prophy

Participating general practices will be randomised to receive a co-designed, tailored and facilitated intervention (virtual educational visits and peer group learning seminars) designed to improve the provision of evidence-based care for either people with gout (Group 1) or older adults prescribed antidepressant medication (Group 2). Each group will act as the other’s control. Key messages of the program for gout will include: - Start urate-lowering therapy at a low dose - Commence flare prophylaxis concomitantly with urate-lowering therapy - Slowly titrate urate-lowering therapy to achieve target serum urate levels and monitor regularly Key messages of the program for older adults prescribed antidepressants will include: - Tailor antidepressant choice to the individual and use informed consent to agree on treatment goals and patient expectations - Review antidepressant treatment early and regularly, assessing the need for additional support to optimise outcomes - GPs and patients to develop a plan for the safe reduction or cessation of antidepressants that incorporates appropriate supports The virtual educational visits and peer group learning seminars will be delivered online by an experienced education facilitator. Virtual educational visits involve a trained facilitator meeting with health professionals (general practitioners (GPs), practice nurses and pharmacists) in their practice setting to deliver information with the aim of improving care. The experienced education facilitator will discuss the key messages of the program for gout and antidepressants topics, explore barriers to best practice and provide strategies (e.g., clinical care scenarios) to support best practice care. The education is tailored to the needs of the health professionals and the practice. A case study may be used to highlight salient points. Although health professionals other than GPs may be involved in the educational visits, this trial focusses on GP outcomes. Peer group learning seminars involve a trained facilitator meeting with health professionals from multiple settings to deliver education with the aim of improving care. The experienced education facilitator will discuss the key messages of the program for gout and antidepressants topics and may use a case study to highlight salient points. Large groups will be separated into smaller groups (up to 10 participants) for break-outs and facilitated discussions. Seminars will generally include a subject matter expert (eg specialist or specialised GP) sharing expert commentary of the topic. Sessions encourage discussion and exchange of ideas between participants. GPs within each practice will be offered a virtual educational visit and/or a peer group learning seminar for the topic to which they are randomised (i.e. gout management or antidepressant prescription in older adults) at a time which has been mutually negotiated. The duration of engagement with each intervention will be approximately 45-60 minutes. Facilitated and tailored educational interventions for adults with gout will be offered from 1 August 2024 until 31 January 2025 while these educational interventions for antidepressant prescription in older adults will be offered from 1 November 2024 until 30 April 2025. These end-dates will be flexible to optimise participation. The facilitator with record participant attendance and complete a checklist to monitor intervention fidelity of each intervention. Both groups will have access to webinars, mini-audits, case-based blogs/online modules, podcasts and clinical decision support tools for both topics via the Medcast online education platform, and access to these will be recorded.

Sponsors

Monash University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Educational / counselling / training
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

GPs registered and practising in Australia and working in a general practice within consenting Primary Health Networks in NSW and Victoria who contribute data to the POpulation Level and Analysis Reporting (POLAR) database. Eligible people with gout will be active patients (defined as attending a general practice three or more times in the past two years), aged 18 years or over with a diagnosis of gout, operationalised as: - a diagnostic code of gout, tophaceous gout, or tophi in patient record (SNOMED Text chronic gouty nephropathy, date gout treatment started, gouty tophus, gout, articular gout, and/or tophus) and/or - prescription of allopurinol, and/or febuxostat and/or - confirmed identification of monosodium urate crystals under polarised microscopy in synovial or bursal fluid or tophi or - detection of urate crystal deposition by ultrasound or dual-energy CT (DECT) People prescribed colchicine without any other confirmatory evidence of gout will be excluded. Eligible older adults will be active patients (defined as attending a general practice three or more times in the past two years), aged 65 years or over or aged 50 years and over in those who identify as being of Aboriginal and/or Torres Strait Islander origin with a diagnostic code of anxiety or depression.

Exclusion criteria

Trainee GPs will be excluded

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 14, 2026