None listed
Conditions
Brief summary
This is a randomised, blinded, placebo-controlled pilot study examining the effect of Urolithin A (UA) supplementation on 18 - 30 year old elite academy soccer players preseason training adapations through a six week preseason. UA (as Mitopure) will be given once per day on each training occasion throughout the six week preseason and training adaptations will be assessed through changes in aerobic capacity (YoYo IRT2), strength and power, and maximal sprint speed. Urine and saliva will be analysed for changes in oxidative stress across the six weeks, and perceived stress will be captured weekly throughout the six week preseason period. It is hypothesised that UA will assist players in developing training adaptations such as strength, power, and aerobic fitness throughout the preseason period.
Interventions
Supplement containing Mitopure -
Sachet containing 1000 mg of Urolithin A (Mitopure) given once per day on each training occasion throughout the six week preseason period. Sachet given with at least 250 mL full cream milk (or similar fat content alternative 'milk') dissolved in their usual protein drink supplement. This will be given and supervised by research staff and recorded on each occasion.
Sponsors
University of Newcastle
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject)
Eligibility
Sex/Gender
Male
Age
16 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
We will be seeking players aged between 16-30 years of age (male), who train with the Central Coast Mariners National Premier League team throughout the preseason period (2024-2025). To participate, they must be actively training with, or planning to train with the Mariners throughout the 2024-2025 preseason period, and are required to be free of any medical conditions that may identify them to be at higher risk of injury or discomfort during the activities. Participants should have no pre-existing medical issues that may be worsened because of testing which is part of the research project. This will be determined by the relevant medical professionals within the department (e.g., doctor, physiotherapists). Players who are at higher risk of injury through participation would be flagged as such by the relevant medical professionals (e.g., doctor, physiotherapists) within the department and will not participate. If a player withdraws from the training environment, or is unavailable for retesting at the end of the preseason period, that information and the reason for that (e.g., injury, signing with another team) will be recorded for descriptive purposes. Players will be given a three day window of availability at the beginning and end of the preseason to have their data recorded through the standard procedures if they are unavailable on the testing date.
Exclusion criteria
- Subjects with diagnosed medical conditions who are unable to participate in training throughout the six week preseason period - Subjects who are unable to complete the training or testing protocols
Outcome results
None listed