None listed
Conditions
Brief summary
The study aims to compare periapical healing in teeth with symptomatic apical periodontitis undergoing root canal treatment with periapical injection of I-PRF versus root canal treatment alone
Interventions
40 teeth from systemically healthy patients with periapical radiolucency and without abscesses were selected, which were randomly divided into two groups of 20 each. Both groups were medicated for two weeks with triple antibiotic paste (TAP) consisting of ciprofloxacin, metronidazole, and minocycline, sealed with Teflon tape and a temporary dressing (Cavit, 3M) in the access cavity. A single endodontist did this procedure.
In control group A, the single cone obturation technique was done alone.
40 teeth from systemically healthy patients with periapical radiolucency and without abscesses were selected, which were randomly divided into two groups of 20 each. Both groups were medicated for two weeks with triple antibiotic paste (TAP) consisting of ciprofloxacin, metronidazole, and minocycline, sealed with Teflon tape and a temporary dressing (Cavit, 3M) in the access cavity. A single endodontist did this procedure. In control group A, the single cone obturation technique was done alone. In contrast, in trial group B, 4ml of blood was drawn into sterile, non-coated plastic PET tubes and centrifuged at 700 rpm (60 g) for 3 minutes to make I-PRF, which was injected immediately before single cone obturation. The complete procedure took an average of 2 hours. Again the same endodontist did this procedure to completion. Preoperative radiographs and postoperative radiographs were taken for all the participants at a follow-up of 4 months using the Orstavik Periapical Index (PAI). Two endodontist observers scored the preoperative and postoperative radiographs using PAI for every patient.
Sponsors
riphah international univeristy
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
• Teeth requiring endodontic treatment with a PAI score of 2 or above in adult patients (above 20) • Teeth with single root and single canal • Percussion test positive or negative • Patients with mature tooth roots • Patients with necrotic tooth • Teeth with a diagnosis of irreversible pulpitis • Pulp test negative or positive • Patients not taking any antibiotics or analgesics before treatment • Age between 20 and 60 years at 4 months follow-up
Exclusion criteria
• Perforated teeth with poor prognosis • Broken down root (Bdr)/ unrestorable teeth/grossly carious teeth • Patients with immature roots • Patients with systemic diseases • Teeth with internal or external root resorption • Previously endodontically treated teeth • Patients with draining abscesses or chronic sinus tract • Teeth with multiple roots or multiple canals • Patients aged 60 or above • Patients aged 20 or below
Outcome results
None listed