None listed
Conditions
Brief summary
The aim of this project is to explore the effects of an acute bout of exercise (before and after a training intervention) and the chronic effects of a 12-week resistance vs aerobic training program on acute and resting expression of signalling proteins, known as myokines, and their cancer-suppressive effects, in relation to body composition, in breast cancer survivors. Who is it for? You may be eligible for this study if you are a woman with stage I-III breast cancer who has completed primary treatment at least 4 months prior to commencing this trial, and have been medically cleared for exercise. Study details Participants will be randomly allocated to a 12-week exercise program involving either resistance or aerobic training. In the weeks immediately before and after the 12-week program, participants will also complete an acute bout of exercise. Participants will be asked to provide blood and complete questionnaires and physical testing before and after the acute bouts of exercise and 12-week program. It is hoped that findings from this study shed light into the mechanisms behind exercise's effect on breast cancer management.
Interventions
Firstly, participants will be randomly allocated, using a digital software, to aerobic or resistance training group.
After one week of familiarization where participants will be guided to the exercise training session with an accredited exercise physiologist, participants will perform a single bout of resistance training at moderate to high intensity for approximately 60 minutes under supervision of accredited exercise physiologist, 1 to 1 in the gym (acute session 1). Intensity will be measure
Firstly, participants will be randomly allocated, using a digital software, to aerobic or resistance training group. After one week of familiarization where participants will be guided to the exercise training session with an accredited exercise physiologist, participants will perform a single bout of resistance training at moderate to high intensity for approximately 60 minutes under supervision of accredited exercise physiologist, 1 to 1 in the gym (acute session 1). Intensity will be measured using rating perceived of exertion 0-10, % of repetition maximum. For the resistance training, machine-based exercises including chest press, leg press, seated row, leg curl, push press, leg extension, pull down, lunges will be used. One week after, participants will commence a 12-week of resistance training, 3 times per week for 60 minutes, with an intensity ranging from moderate to high, under supervision of accredited exercise physiologist in small groups in the gym (3 to 4 participants) (chronic intervention). Intensity will be measured using rating perceived of exertion 0-10, % of repetition maximum. Adherence will be monitored using a checklist. For the resistance training, machine-based exercises including chest press, leg press, seated row, leg curl, push press, leg extension, pull down, lunges will be used. Lastly, one week after the conclusion of the 12-week of training program, participants will perform another single bout of resistance training at moderate to high intensity for approximately 60 minutes under supervision of accredited exercise physiologist 1 to 1 in the gym (acute session 2). Intensity will be measured using rating perceived of exertion 0-10, % of repetition maximum. For the resistance training, machine-based exercises including chest press, leg press, seated row, leg curl, push press, leg extension, pull down, lunges will be used.
Sponsors
Edith cowan university
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to 74 Years
Healthy volunteers
No
Inclusion criteria
To be included in the current study, subjects have to meet the following inclusion criteria: 1) women with stage I-III breast cancer; 2) with or without endocrine therapy; 3) completed primary treatment (e.g., chemotherapy, radiation therapy, surgery) at least 4 months prior; 4) BMI between 18.5 and 35 kg/m2; 5) medically cleared for exercise; and 6) willing and able to comply with all study requirements, including treatment, timing and/or nature of required assessments.
Exclusion criteria
The exclusion criteria are: 1) any known absolute contraindication to exercise; 2) currently completing vigorous exercise in the past 3 months (i.e., Aerobic training more than 150 or 75 minutes at moderate or high intensity respectively, or resistance training more than 2 sessions per week at moderate to high intensity); 3) life expectancy less than 12 months; and 4) pregnant or lactating. Additionally, subjects will be required to maintain their habitual diet throughout the training program.
Outcome results
None listed